Advantix For Large Dogs 21-55lbs (Red) free shipping at Easyvetsupplies.com Advantix / K9 Advantix comes basically like a combination of two active ingredients such as Imidacloprid and Permethrin. Both are effective in repelling killing ticks, fleas, flies, and mosquitoes. These ingredients are sufficient to get deeper into the skin layer and attack the sitting parasite's nerve cells. By affecting the parasites' nervous system, the treatment kills them and stops the larvae from giving further birth. Advantix kills 98-100 % of fleas within 12 hours and continues working for one month to prevent infestations. The outside parasites include fleas, ticks, mosquitoes, sandflies, etc.