Current developments in bioinformatics and computational biology A systematic review - Pubrica
                     Current Developments in Bioinformatics and Computational Biology: A 
Systematic Review 
 
 
Dr. Nancy Agnes, Head, 
Technical Operations, Pubrica 
[email protected] 
 
 
 
In-Brief multilingual knowledge to use recent 
 bioinformatics sources powered with 
Bioinformatics includes information advanced operating systems, software, and 
technology and computers to large database/networking technologies. 
molecular biology data sets. Bioinformatics A systematic review paper helps create a 
is anticipated as a cutting-edge branch of review that formulates a question that 
the biotechnology sector, which help in uses systematic and reproducible methods to 
drug innovation and personalized medical identify, select and critically appraise all 
treatments. The field closely associates relevant research, and gather and analyze 
artificial intelligence and computer science data from the analysis included in 
with microbiology and genomics. the Review.  
  
Keywords: systematic review services, II. SYSTEMATIC REVIEW WRITING 
conducting a systematic review, systematic  
review paper, systematic review writing Bioinformatics encourages prospects for 
service, Systematic Review writing help, novel discoveries and reveals pathways for 
systematic review writing, systematic review biological experiments with the support of 
writing help data analysis. Research in this field mainly 
 depends on high-quality databases to offer 
I. INTRODUCTION precise outcomes. However, most biological 
 databases have obtainable mistakes, such as 
Bioinformatics is an interdisciplinary field data wrongly classified or incomplete 
of life sciences that develops methods and information. These mistakes may be 
software tools that help understand problematic. Recent data mining algorithms 
biological data, particularly when the data may use the filter data. However, sometimes 
sets are large.  Its application and research these algorithms cannot treat these faults, 
comprise genomics data analysis, genome leading to severe problems for analysis. 
annotation, molecular folding, gene/protein Manual data curation and extracted data 
prediction and molecular sequence. It also from literature is a solution to this problem. 
includes developing databases and data For example, a database of mutations effects 
management systems, software and analysis on protein-ligand affinities, composed of 
tools. 1,000 mutations, was generated through a 
Bioinformatics education and training are deep search in the literature. Nevertheless, 
necessary to understand the basics and the manual analysis may be address bias 
specifics of bioinformatics and create new risk, which may not collect all possible data 
generation specialists and scientists with necessary for a determined study.  
integrated, interdisciplinary, and 
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Manual curation also permits the It is used in designing the structuring of 
identification of mistakes and, when biological molecules and enzymes. There 
possible, corrects them. Therefore, are few examples where they are widely in 
systematic literature reviews used to collect use de novo protein design, protein-peptide 
data for bioinformatics analysis. Systematic interaction, protein-ligand/drug docking, 
Review is a technique used to discover, enzyme design, macromolecular complexes, 
estimate and summarize the state-of-the-art and structure prediction of biological 
of a precise theme in the literature. macromolecules. It supports the prediction 
Systematic Review writing helps gather that the structure of a protein depends on the 
literature information restrictively that known structure of a homologous protein(s).  
allows a rigorous methodological analysis Apart from that, the discovery of secondary, 
with lower prejudice than the traditional tertiary, and quaternary structures of 
reviews. Conducting a systematic review, proteins is significant to understand proteins' 
the objective is to build a general vision of a function. The exact three-dimensional 
specific question and give it a reasonable structure is necessary for correct function, 
summary of the literature. To perform and a failure to fold into native construct 
systematic reviews is essential to follow a generally produces inactive proteins or 
pre-established and well-defined protocol.  misfolded proteins that can be toxic. 
Following the distinct systematic steps may  
guarantee the reproducibility of the study.  
Some monitors have been proposed to help 
commentators to construct Systematic 
Literature Review. Also, estimation 
approaches of Systematic Literature Review 
quality, such as the PRISMA declaration, is 
which PRISMA (Preferred Reporting Items 
for Systematic Reviews and MetaAnalyses) 
describes a set of items to help authors 
advance the reporting of Systematic 
Literature Review.  
 
III. STRUCTURAL BIOINFORMATICS: 
MOLECULAR FOLDING, MODELLING, 
AND DESIGN 
 
One of the commonly used applications of  
bioinformatics is the identification of three-  
dimensional protein molecular modelling,  
structure, and folding to forecast the  
possible function of proteins or model IV. BIOLOGICAL NETWORKS AND 
behaviour of molecules, other molecular SYSTEM BIOLOGY 
structures, fold the molecule to its natural  
biologically functional three-dimensional The properties of network topology are 
structure and help in creating biomedical widely applied in many scientific fields, 
drugs for various complicated human including bioinformatics, leading to the 
diseases. construction of large-scale biological 
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networks represented as "omes" like biome, generation of bioinformatics tools and 
interactome, microbiome. software that are user-friendly and must 
The above emphasized molecular sequence perform integrated and extended analysis 
analysis, annotation, prediction, and with better visualization and graphical 
molecular modelling-associated to outputs.  
bioinformatics methods are also the Some of the open-source software packages 
principal for organizing, building, and include UGENE, EMBOSS, GenGIS, 
genetic and biochemical pathways of GENtle, BioPerl, PathVisio, GenoCAD, 
complex cellular processes. These signal GenomeSpace, Biopython,  Bioclipse, 
transduction comprise reception, and gene GeWorkbench, .NET Bio, Apache Taverna, 
co-expression and gene regulation. Such BioJS, Bioconductor, BioJava, and 
molecular networks incorporate various data BioRuby. 
types, including DNA sequences, regulatory  
RNA, proteins, gene expression data, VI. TEXT MINING 
secondary metabolites, and other small  
molecules, which may be connected Bioinformatics research and application aim 
physically and functionally. The structuring to use computational algorithms and 
and organization of such physically and bioinformatics tools to gather, construct, and 
functionally connected molecular networks structure the increasing body of biomedical 
of cellular processes can be achieved only literature permutes scientists to question, 
by applying the combination of simulative, mine, study, and synthesize the particular 
iterative, and model-oriented bioinformatics literature and published articles of their 
approaches.  research interest. 
 Therefore, text mining and biomedical 
V. SOFTWARE, ANALYSIS TOOLS, literature play a significant role in the 
SERVICES, AND WORKFLOW scientific enhancement, inventions, and 
 application and integration of discoveries to 
The key driving force for the present and society through extracting information (EI) 
future development of bioinformatics and assessing the relationships of 
software and tools, which help in the publications.  
progress of genome decoding technologies, Biomedical literature text mining uses 
consequent required for their analyses, various "text mining & data mining" tools, 
accretion of large volume biological data, as visualization and navigation, information 
well as the development of computer retrieval, applying techniques such as data 
technologies, visualization, graphics, and clustering and extraction, and text 
networking techniques and molecular categorization and summarization.  
modelling.  
Moreover, the availability of numerous VII. CONCLUSION 
shared object models, open-source codes,  
and community-maintained plug-ins helps Systematic literature reviews used to collect 
collect new ideas from the community and data for bioinformatics analysis. It is a 
perform innovative in silico experiments on technique used to discover, estimate and 
current "Big Data." summarize the state-of-the-art of a precise 
 These all make way for research groups and theme in the literature. Systematic Literature 
bioinformatics corporations to experiment, Review permits gathering literature 
work, and create a more innovative information restrictively that allows a 
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rigorous methodological analysis with lower 
bias than the traditional reviews. The 
objective is to build a general vision of a 
specific question and give it a reasonable 
summary of the literature. Hence, to perform 
systematic reviews is essential to follow a 
pre-established and well-defined protocol.  
 
REFERENCES 
 
1. Zomaya, A. Y. (2005). Parallel computing for 
bioinformatics and computational biology. Wiley. 
2. Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, 
B., Dettling, M., Dudoit, S., ... & Zhang, J. (2004). 
Bioconductor: open software development for 
computational biology and bioinformatics. Genome 
Biology, 5(10), 1-16. 
 
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