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Particularly when used for an extended period of time, tramadol 
may lead to addiction. Follow the directions on tramadol precisely. 
Never take more of it, take it more frequently, or take it differently 
than your doctor has prescribed. Talk about your pain management 
objectives, duration of treatment, and alternative pain 
management techniques with your healthcare professional while 
using tramadol. Buy Tramadol Ultram Online if you or anyone in 
your family consumes or has consumed significant amounts of 
alcohol, uses or has consumed street drugs, overuses prescription 
drugs, has experienced an overdose, or has depression or another 
mental disease, let your doctor know. 
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Tramadol seems to compete with 5-HT in order to affect serotonin (5-
HT) absorption processes. It increases the release of serotonin that is 
induced by stimulus once it is inside the presynaptic terminal. This 
implies that tramadol may directly affect serotonin release without 
reuptake inhibition, which may contribute to its complex pain-relieving 
properties. Crucially, despite being a stronger opioid, tramadol's 
metabolite M1 does not exhibit this effect, suggesting that the capacity 
of tramadol and its racemic combination to boost 5-HT release is not 
connected to opioid receptor activation.
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