CBD Oil
                     CBD Oil
Offset Anxiety and Depression
CBD’s ability to calm is perhaps its most popular effect and the reason its use is so 
widespread. A 2017 study in the Brazilian Journal of Psychiatry tested the anxiety levels 
of 57 men in a simulated public speaking test. Some received a placebo while others 
received either 150 milligrams, 300 milligrams or 600 milligrams of CBD before their 
speeches. Those who received 300 milligrams of CBD experienced significantly reduced 
anxiety during the test compared to those who received the placebo. Interestingly, 
participants who received either 150 or 600 milligrams of CBD experienced more anxiety 
during the test than the 300 milligrams group.
Meanwhile, at least one study in mice revealed CBD had effects similar to the 
antidepressant imipramine. Human trials are needed, though, to confirm whether CBD 
can induce this same antidepressant reaction in our bodies.
Ease Diabetic Complications 
For starters, tests on human cells found that CBD helps reduce the effects of high glucose 
levels on other cells in the body, which typically precedes the development of diabetes 
and various complications. Researchers concluded that with further studies, CBD could 
have significant benefits when used in patients with diabetes, diabetic complications and 
plaque buildup in artery walls.
In another small study, 13 patients with type 2 diabetes who weren’t on insulin treatment 
were given both CBD and a placebo (in lieu of insulin). Researchers found CBD decreased 
their levels of resistin (which causes resistance to insulin, the protein that regulates sugar 
levels) and increased their levels of glucose-dependent insulinotropic peptide (a hormone 
that ensures a sufficient release of insulin from digested food) compared to their 
baselines before they started the test. These results suggest CBD could be a natural 
treatment for diabetes by helping the body regulate insulin-related hormone levels.
Treat Select Epilepsy Syndromes
In some instances, CBD can be used to treat epileptic seizures.
In 2018, the Food and Drug Administration (FDA) approved the use of CBD under 
the brand name Epidiolex to treat seizures resulting from Lennox-Gastaut 
syndrome and Dravet syndrome—two rare forms of epilepsy—in patients at least 2 
years old.
Three well-vetted studies provide the basis of support for the FDA’s decision. In 
these trials, 516 patients with Lennox-Gastaut syndrome or Dravet syndrome 
received either Epidiolex or a placebo. Epidiolex, when taken along with other 
prescribed medications, decreased the frequency of participants’ seizures 
compared to the placebo.
Reduce PTSD Symptoms
In a small 2018 study in the Journal of Alternative and Complementary Medicine, 
11 people with post-traumatic stress disorder (PTSD) received CBD along with 
routine psychiatric care for eight weeks in an outpatient psychiatric clinic. Ten of 
the 11 experienced a decrease in their PTSD symptoms. CBD was generally well 
tolerated, the researchers write.
Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and 
CBD, emphasizes the importance of using therapy in tandem with any type of 
cannabis or CBD for PTSD. “There is an amount of therapy that is needed for 
PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”
Treat Opioid Addiction
Some studies—both preclinical animal and human clinical trials—suggest CBD 
could be used to help treat people who are dependent on opioids.
In one such study, researchers administered CBD to people with heroin use 
disorder. Over the course of a week, CBD significantly reduced heroin users’ cue-
induced cravings, withdrawal anxiety, resting heart rate and salivary cortisol 
levels. No serious adverse effects were found.
Alleviate ALS Symptoms
Amyotrophic lateral sclerosis (ALS) is a disease that causes nerve cells in the brain 
and spinal cord to deteriorate, resulting in loss of muscle control that worsens over 
time. It’s not yet understood exactly why ALS occurs, although it can be hereditary in 
some cases. There’s no known cure, and there are only two FDA-approved 
medications to help treat ALS symptoms.
Research suggests people with ALS can benefit from the entourage effect created by 
the combination of THC and CBD, similar to people with PTSD. In a 2019 study, 
patients received a combination of THC and CBD in varying doses depending on 
their needs and preferences. Those with mild, moderate or severe spasticity (muscle 
tightness and stiffness) due to ALS reported high levels of satisfaction with the 
treatment, and those with moderate to severe spasticity reported higher satisfaction 
rates than those with mild spasticity.
Relieve Unmanageable Pain
In 2005, Canada approved the use of Sativex, an oromucosal (absorbed in the lining of 
the mouth) spray with equal proportions of THC and CBD, for the treatment of multiple 
sclerosis-related central neuropathic pain. In 2007, Canada approved the medicine’s 
use again for cancer pain that proved unresponsive to other medications.
Meanwhile, continued studies in the U.S. indicate CBD is effective in treating chronic, 
non-cancer pain. In one 2020 study, researchers administered CBD topically to a group 
of patients with symptomatic peripheral neuropathy (a result of brain nerve and spinal 
cord nerve damage) while another group with the same condition received a placebo. 
Results showed a significant reduction in intense, sharp pains and cold, itchy 
sensations in those who used the topical CBD compared to those who used the 
placebo. No participants reported adverse side effects.
Thank You
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