Stroke increases the susceptibility to neuronal damage leading to an overall loss in cognitive and motor functions. Following the acute phase of stroke, patients are currently recommended thrombolytic agents; nevertheless, many patients have enduring effects. While stem cell therapy post infusion can incorporate into the host brain and replace dead/damaged brain cells, reduce lesion size, and inhibit cell death suggesting an important role in cell-induced neuroprotection, immunomodulation, and downregulation of inflammatory responses.