Paper TSC June 2021
                     Research paper of Dr. Trupti Chitre
Title: Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for 
            Antitubercular Activity: A Review
Authors: Trupti Sameer Chitre*, Kalyani Dhirendra Asgaonkar , Shital Manoj Patil , Muthu 
                   Kumaradoss Kathiravan and Subhash Balkrishna Padhye
Journal Details: Current Topics in Medicinal Chemistry, 2016, 16, 3211-3223
Publisher: Bentham Science Publishers
Description: 
Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of
M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally
drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the
current  situation necessitates  developing  new antitubercular  agents  acting  on  novel  targets  for
effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target,
which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and
computational  studies  of  various  nucleotide  and  nucleoside  derivatives  of  pyrimidine  analogs
reported as TMPKmt inhibitors.
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