Denosumab 60 mg vs 120 mg is a comparison hospital pharmacies run into often, because the same medicine is stocked in two very different forms under two different brand names. The 60 mg product (sold as Prolia) and the 120 mg product (sold as Xgeva) contain the same antibody, yet their approved uses, labelled schedules and safety warnings are not the same. This guide sets out what the US prescribing information and the published trials report for each strength, why the two are not swapped for one another, and what that means for procurement teams in India.