Arrive Guidelines for Preclinical Studies
                     
Arrive Guidelines for 
Preclinical Studies: 
Importance in 
Bioscience Research 
Reporting
Introduction
ARRIVE guidelines are important for 
good reporting of the research 
conducted on animals. There are 
various advantages to following 
ARRIVE guidelines. Following these 
guidelines will increase validity and 
transparency in research articles and 
will become the guiding light for 
further research.
Need and Importance of Good Reporting
In the present times, several journals are 
involved in publishing the latest researches 
on biosciences. To provide accurate 
information to the readers, good bioscience 
reporting related to the preclinical studies is 
of utmost importance. 
Following are the various advantages of good 
bioscience reporting in articles related to 
pre-clinical studies:
 Quality information dissemination: Good 
reporting ensures that quality information is 
disseminated in the scientific community. 
 Helpful in advanced research: When the 
research article report of high-level, and all 
the minute information are presented in a 
detailed manner, it will become a guiding 
light for further research, whether a 
preclinical or clinical. 
 Optimum utilization of resources: Good 
reporting helps the researchers all over the 
world to make optimum utilization of 
resources. It has been found that bad 
scientific reporting has ethical, scientific, and 
economic repercussions.
 Make the research more relevant: Good 
reporting helps the researcher to make its 
research more relevant among the scientific 
community. If the reporting of 
preclinical research is of high-quality, other 
authors will use it as a reference which 
increases the authenticity of research.
 Effective peer review process: Most 
journals conduct a peer-review process. 
Good journals have a stringent peer-review 
process and substandard reporting of the 
research may lead to rejection of the article 
for publication. It has been found that many 
articles do have the hypothesis or the 
objective of the research while some have 
not reported the animal selection criteria or 
the type of research.
Why ARRIVE Guidelines is Required?
ARRIVE (Animals in Research: 
Reporting In-vivo Experiments) 
guidelines were developed for 
accurately reporting animal research. 
These guidelines make use of the 
guidelines mentioned in the CONSORT 
statement. The main aim of ARRIVE 
guidelines is to increase the quality of 
research reporting by improving the 
quality and quantity of information 
and to avoid unnecessary studies 
involving animals.
ARRIVE Guidelines
ARRIVE guidelines provides a list of 
information that should be incorporated in 
reporting research in a scientific article
 related to animals. 20 items should be 
reported in the articles. To increase its 
validity and authenticity, the ARRIVE 
guidelines are prepared by taking inputs 
from researchers, journal editors, research 
funders, and statisticians. Following are the 
items that should be included in the 
research study according to 
ARRIVE guidelines:
 Title: Title is an important part of the 
research article. It should be clear and 
concise which depicts the research as closely 
as possible.
 Abstract: Abstract is a brief about the 
complete study. The abstract should include 
research objectives, background, methods, 
key findings, and the conclusion.
 Introduction: The introduction includes 
background and objectives. The background 
explains what has already been done before 
the research in context. Primary and 
secondary objectives define what the 
researcher wants to achieve with the 
research.
 Methods: Methods include study designs, 
ethical procedures, experimental methods, 
animals, sample size, housing and 
husbandry, the outcome of the experiment, 
and statistical methods used. 
 Results: The result should be provided in 
detail in the research article. The results 
should be directed upon primary and 
secondary objectives. 
 Discussion: This section will determine 
how the outcome of your research fits in 
context to other similar types of 
researches. The study objectives and 
hypotheses are discussed in detail in 
comparison to prior literature.
REFERENCE
Kilkenny C, Browne WJ, Cuthi I, 
Emerson M, Altman DG. Improving 
bioscience research reporting: the 
ARRIVE guidelines for reporting 
animal research. Vet Clin Pathol. 
2012;41(1):27-31. doi:10.1111/j.1939-
165X.2012.00418.x
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