Uploaded on Sep 12, 2022
PPT on Rosalind Franklin
Rosalind Franklin: Key figure in DNA Structure Discovery
ROSALIND FRANKLIN: KEY FIGURE IN DNA
STRUCTURE DISCOVERY
INTRODUCTION
Rosalind Franklin, in full Rosalind Elsie Franklin, (born July
25, 1920, London, England—died April 16, 1958, London),
British scientist best known for her contributions to the
discovery of the molecular structure of deoxyribonucleic
acid (DNA), a constituent of chromosomes that serves to
encode genetic information.
2
Source: www.britannica.com
A CRUCIAL
CONTRIBUTION
Rosalind Franklin made a crucial contribution to the
discovery of the double helix structure of DNA, but some
would say she got a raw deal.
Biographer Brenda Maddox called her the "Dark Lady of
DNA," based on a once disparaging reference to Franklin
by one of her coworkers.
3
Source: www.nature.com
A CRUCIAL
CONTRIBUTION
CONT.
Unfortunately, this negative appellation undermined the
positive impact of her discovery. Indeed, Franklin is in the
shadows of science history, for while her work on DNA
was crucial to the discovery of its structure, her
contribution to that landmark discovery is little known.
4
Source: www.nature.com
EDUCATION
At age 18, she enrolled in Newnham Women's College at
Cambridge University, where she studied physics and
chemistry. After Cambridge she went to work for the
British Coal Utilization Research Association where her
work on the porosity of coal became her Ph.D. thesis, and
later it would allow her to travel the world as an guest
speaker.
5
Source: www.nature.com
EDUCATION
CONT.
In 1946, Franklin moved to Paris where she perfected her
skills in X-ray crystallography, which would become her
life's work. Although she loved the freedom and lifestyle
of Paris, she returned after four years to London to accept
a job at King's College.
6
Source: www.nature.com
A PASSIONATE
WOMAN
Franklin worked hard and played hard. She was an
intrepid traveler and avid hiker with a great love of the
outdoors who enjoyed spirited discussions of science and
politics. Friends and close colleagues considered Franklin
a brilliant scientist and a kindhearted woman.
7
Source: www.nature.com
AN UNHAPPY
TIME
A misunderstanding resulted in immediate friction
between Wilkins and Franklin, and their clashing
personalities served to deepen the divide. The two were
to work together on finding the structure of DNA, but their
conflicts led to them working in relative isolation.
8
Source: www.nature.com
NOT
ACKNOWLEDGED
Using Franklin's photograph and their own data, Watson
and Crick created their famous DNA model. Franklin's
contribution was not acknowledged, but after her death
Crick said that her contribution had been critical.
9
Source: www.nature.com
STRUCTURE OF
THE TOBACCO
MOSAIC VIRUS
Franklin moved to Birkbeck College where, ironically, she
began working on the structure of the tobacco mosaic
virus, building on research that Watson had done before
his work on DNA.
10
Source: www.nature.com
DEATH
During the next few years she did some of the best and
most important work of her life, and she traveled the
world talking about coal and virus structure. However,
just as her career was peaking, it was cut tragically short
when she died of ovarian cancer at age 37.
11
Source: www.nature.com
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