Unexplained Infertility Diagnosis and Treatment
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You are trying to conceive. You have done all the right things. The tests seem normal. But still, there is no 
pregnancy. This is often where the term “unexplained infertility” comes in. It means everything looks fine on 
paper, yet conception does not happen. It can feel frustrating, but there are clear next steps.
What Is Unexplained Infertility?
Unexplained infertility is a diagnosis made when all standard fertility tests come back normal. Ovulation is 
regular. Sperm count is healthy. Tubes are open. The uterus shows no major issues. But after a year or more 
of trying, there is still no success.
It does not mean there is no reason. It just means the cause has not been found yet. Often, it involves subtle 
issues like egg quality, sperm function at a molecular level, or timing that cannot be seen through routine 
testing.
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What Tests Are Done for Unexplained Infertility?
Before calling it unexplained, doctors will run a full fertility workup.
Ovulation tracking to confirm regular egg release
Hormone level tests for FSH, LH, AMH, prolactin, and thyroid
Pelvic ultrasound to assess the uterus and ovaries
Semen analysis for count, shape, and movement
HSG (hysterosalpingogram) to check the fallopian tubes
STI screenings
Basic genetic screening in some cases
So, what tests are done for unexplained infertility? These are the standard checks. If all results appear normal, 
the diagnosis becomes unexplained infertility.
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What Is the Best Treatment for Unexplained Infertility?
There is no one-size plan. The treatment depends on age, medical history, and how long you have been trying. 
In younger couples, doctors may suggest a few more months of trying with timed intercourse. In others, there 
is the use of assisted methods. What then is the most appropriate treatment of unexplained infertility? The 
most typical ones are as follows:
Ovulation induction with IUI: This is often the first step. It boosts egg release and increases the chances of 
sperm reaching the egg.
In vitro fertilisation (IVF): IVF allows fertilisation outside the body. This bypasses many small factors that may 
be blocking natural conception.
ICSI: A single sperm is injected directly into the egg, used in IVF cycles when there may be hidden sperm 
issues.
The best fertility treatment options will be chosen based on how your body responds and how much time you 
are willing to commit.
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How Successful Is Treatment for Unexplained Infertility?
Many couples do conceive after treatment. IUI success rates are about 10 to 20 percent per cycle. IVF offers 
higher chances, especially when combined with advanced methods like embryo freezing or ICSI.
So, how successful is treatment for unexplained infertility? It depends on age, ovarian reserve, and treatment 
choice. IVF often gives the best outcome within three cycles. Emotional and physical support during this time 
also improves the journey. Connect with the best gynaecologist in Mumbai for infertility to avail immediate 
solutions.
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Final Thoughts: Keep Moving Forward
Unexplained infertility can feel like a dead end. But in reality, it opens the door to closer observation and 
targeted treatment. Many couples in the same situation do go on to have healthy pregnancies.
If the journey feels uncertain, take one step at a time. Ask questions. Track each phase. Work with a doctor 
who listens. Sometimes, the answer is not in the test results but in the personalised care plan that follows.
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Dr Neelima Mantri Contact Details
Bombay Hospital And 
Nanavati Hospital Surya Hospitals VLSR, The Clinic
Medical Research 
101-102, Mangal 
Centre S.V. Road, Vile Parle 
Ashirwad, S V Road, 2nd Floor, Corinthian 
(West), Santacruz West, Building, Opp. DBS 
203, Level 2, New 
Mumbai, Maharashtra Bank,
Wing, Mumbai 400 056, India.
400054. Linking Road, Khar 
12, New Marine Lines,
Monday to Saturday Mon, Tue and Wed 7.00 West, Mumbai 400052.
Mumbai 400020
pm to 8.00pm Monday To Saturday
Monday to Saturday 5.00 pm to 7.00pm
11.00 am to 1.00pm
1:00pm to 4:00 pm
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