https://www.edhacare.com/treatments/organ-transplant/heart A heart transplant is a lifesaving surgery in which a failing or diseased heart is replaced by a donor heart. It is often done in patients with end-stage cardiac failure or critical coronary heart disease in whom all other forms of treatment have not worked. The surgery requires intricate preoperative preparation, donor compatibility matching, and meticulous surgical maneuvers. Patients need lifelong anti-rejection medication and close supervision after heart transplantation. Heart transplants can profoundly enhance the quality of life and long-term survival for suitable patients.