Breaking Barriers in the use of Biomedical Data- Multi-modal Data Management
                     Breaking Barriers in the use of 
Biomedical Data- Multi-modal 
Data Management
Agenda
"The value is in the data, it is not 
in the tools. That is the one thing, 
● Introducing Polly: Platform for it’s a bit of a hobby horse for me. 
managing multi-modal One thing I always point to in 
biomedical data these discussions around data, 
don’t underestimate the amount 
● Example of how to use of time and value in doing what is 
Polly: Analyzing really often difficult and not so 
rewarding directly work, like 
Metabolomics Data cleaning data sets isn’t always 
● Discussion fun, but it is often the most 
valuable thing you can do."
-Dr. Jeffrey Reid,
Regeneron's Chief Data Officer
Leaders in Multi-Modal Biomedical Data Management
with Differentiated Technology & Expertise
1 30+ customers deriving value from our technology and expertise.
2 A malleable cloud friendly technology that can seamlessly fit into your R&D Ecosystem.
3 With a team that can quickly assimilate industry domain into high value services.
Polly, A Scalable Platform for Multi-Modal Data Management
Data Harmonization & Data Storage & Data Consumption
Ingestion Management
Polly Pipelines Polly Atlas Polly Apps
Workflow orchestration Custom apps running on a For storing structured 
system(supports Nextflow) highly scalable infra (Hail, data in a data model
IGV)
Polly Curation Polly Workspaces Polly Notebooks  
Manual and automated For storing unstructured Data exploration/analysis 
data curation data using Jupyter notebooks
Polly Sync
Import files from many 
external sources
25+ Data types Supported PBs Integrof Data stored 10+ BI Analysis& 
aotins to ML,
oolsT 
35 of datasets processed and < To query millions of TBs harmonized / month secs records at once 17+
15 Propri etary  W -beApplications deveolped
Polly brings value on day 1 and can evolve as your analytics needs evolve
1 2 3
Managed In-built Data 
Raw multi-omics 
Cloud Security & 
Data to Insights
Platform Governance
With Polly -  Fully Managed Cloud 
Platform From Day 1
Building this in-house could take 2 years, 15+ 
Engineers and millions of dollars
Benefits of a fully managed cloud platform:
● New institutes can be easily onboarded 
on the same platform
● Support and maintenance included, 
with 99% uptime.
● Secure collaboration across users, 
multiple sites and stakeholders with 
granular access controls
With Polly -  In-built Data Security 
& Governance
Baking in security & compliances into a data 
platform takes an additional 6 months
With Polly your data is secure from day 1:
●Compliances Supported: SOC 2, GDPR, 
HIPAA
●Platform supports single sign on (SSO) 
services for multiple simultaneous users 
and role based access control.
●Enterprise-grade Authentication 
and Authorization.
●Deployment not dependent on 
geography.
With Polly -  Accelerate Raw Data to 
Insights by Multi-Fold
Scalable Infrastructure that supports:
● Harmonization & Analysis of 25+ 
Data Types
● 2X Cheaper data processing than 
vanilla AWS
● Ingestion, processing & 
harmonization of 5000 samples per 
week
● Seamless Integration of new 
applications or pipelines on 
Polly’s cloud infrastructure. $
From Raw Data to Insights: Data Journey on Polly
Data Data Data Data 
Ingestion Storage Management Visualization
Intuitive 
Simplified data Store multi-modal Data governance, 
applications to 
ingestion via GUI or data on Polly access controls & 
streamline insight 
CLI Atlases permissions
generation
Eliminate Manual Data Transfers with Polly Ingestion
Data Data Data Data 
Ingestion Storag Manageme Visualization
e nt
Custom GUI for Data Ingestion 5000 samples can be ingested weekly
Harmonize & Index Data on a Polly Atlas
Data Data Data Data 
Ingestio Storage Manageme Visualization
n nt
● Processed, annotated with critical metadata  & 
ǪC-ed with harmonization engine
Multi-modal data is harmonized, integrated & ○LLM-powered harmonization accelerates 
Indexed on Polly Atlases metadata annotation by 10X
○Values & Metadata validated by experts
● Common Data model provides relational link 
between Patient metadata and molecular data
Manage Sensitive Data & Projects over Workspaces
Data Data Data Data 
Ingestio Storag Management Visualization
n e
● Unified view of raw data, processed data 
& corresponding results, in the same 
Eliminate Data Silos, manage permissions location
& control access to sensitive data assets
● Version control data, metadata & 
analyses.
● Control permissions & provide the right 
access controls
to data & projects on Workspaces
Streamline insight generation with Intuitive Applications
Data Data Data Data 
Ingestio Storag Manageme Visualization
n e nt
● Simplified data exploration via custom filtering options on an Atlas UI
● Seamless comparison across patient cohorts with integrated multi-
source data
● Visualize & analyze on native apps like Phantasus, IGV or Intomix
● Connect with external tools like Spotfire with APIs
Thank 
You