Peyronie's Disease (Penile Curvature)
                     Peyronie's Disease 
(Penile Curvature) 
Introduction 
to Peyronie's 
Disease
Peyronie’s disease is a condition characterized by the 
formation of fibrous scar tissue, or plaques, under the 
skin of the penis, leading to a noticeable curvature 
during erections. It affects approximately 1 in 10 men, 
making it a relatively common urological issue. Beyond 
physical symptoms, Peyronie’s disease can 
significantly impact men's emotional well-being and 
sexual health, contributing to conditions such as 
erectile dysfunction and emotional distress, which can 
strain personal relationships and self-esteem.
Symptoms of 
Peyronie's 
Disease
Penile Curvature Penile Pain Erectile Dysfunction
The most noticeable symptom is an Many individuals experience pain during Scar tissue can disrupt normal erection 
unusual curve of the penis during an erections, which can range from mild mechanics, leading to difficulties in 
erection, which can vary in direction discomfort to severe throbbing. achieving or maintaining an erection.
and severity.
Penile Shortening Emotional Distress Penile Deformity
Peyronie's disease may cause a Physical symptoms can lead to In addition to curvature, abnormalities 
noticeable reduction in penis size, psychological issues, including anxiety may include indentations or constriction 
particularly when erect, due to scar and depression, affecting self-esteem during an erection due to fibrous 
tissue. and relationships. plaques.
Causes of 
Peyronie's 
Disease
Trauma or Injury Genetics Abnormal Healing Response
Penile trauma, whether acute or Research suggests a genetic Men with Peyronie's disease may 
chronic, often initiates Peyronie's predisposition may influence the experience dysregulated healing 
disease by causing localized likelihood of developing Peyronie's processes, leading to excessive collagen 
inflammation and aberrant scar tissue disease, particularly in those prone to deposition and plaque formation.
formation. abnormal scar tissue.
Connective Tissue Disorders Inflammation in the Penis Age and Hormonal Factors
Certain connective tissue disorders, Inflammation, driven by injury or other Men over 40 are more commonly 
such as Dupuytren’s contracture, triggers, initiates the fibrotic process, affected, but increasing reports in 
increase the risk of developing scar resulting in plaque formation within the younger men suggest hormonal 
tissue in the penis. penile tissue. imbalances may also play a role.
Self-Healing Possibilities
Peyronie’s disease can heal on its own in 
approximately 13% of men within 6 to 15 
months. This spontaneous resolution may occur 
as the scar tissue is naturally absorbed by the 
body. Factors influencing self-healing include the 
extent of the plaque formation, the severity of 
symptoms, and individual healing responses. 
However, many cases remain persistent, 
necessitating medical intervention for effective 
treatment.
Diagnosis of Peyronie's Disease
Medical History Review The diagnosis begins with a thorough review of the patient's medical 
history, including any previous penile trauma, surgical history, and 
family history of Peyronie's disease.
Physical Examination A physical examination is conducted to assess penile curvature, identify 
any palpable plaques, and evaluate erectile function through various 
tests.
Imaging Tests Imaging tests such as ultrasounds may be utilized to visualize the 
plaque location and size, aiding in assessing the severity of the 
condition.
Treatment Options
Medications Oral medications like collagenase (Xiaflex), pentoxifylline, and calcium 
channel blockers may be prescribed to reduce plaque size or alleviate 
symptoms.
Surgery In severe cases, surgical options such as plaque incision/excision, 
penile implants, or grafting may be necessary to correct curvature and 
restore function.
Shockwave Therapy High-energy shockwave therapy is used to enhance blood flow and 
break down plaque, but results have been limited and are considered 
controversial.
Injections Collagenase injections can be administered directly into plaques to 
help break down scar tissue and improve curvature.
Home Remedies for Curvature
Gentle Stretching Exercises Penile Traction Therapy Vitamin E and Herbal 
Supplements
Regular gentle stretching can Using a penile traction device Some studies suggest that 
improve flexibility and may help applies consistent, gentle vitamin E and supplements like 
in gradually reducing the pressure to the penis, CoQ10 may reduce plaque 
curvature. Stretching the penis potentially straightening it over buildup associated with 
in the opposite direction of the time. Many men have reported Peyronie’s disease. Consult a 
curve for a few minutes daily is gradual improvements with healthcare provider before 
recommended. proper use. starting any new supplements.
Key Takeaways and FAQs
Frequently Asked 
Key Takeaways Questions
● Peyronie's disease affects 1 in 10 men, ● Peyronie's disease can affect perceived 
causing penile curvature and pain. size due to curvature and scar tissue.
● Symptoms include erectile dysfunction, ● It is not life-threatening but can impact 
penile shortening, and emotional distress. sexual function and emotional health.
● Diagnosis is made through medical history ● Pain during erections is common and 
and physical examinations. can vary in intensity.
● Treatment options vary from ● Self-treatment options include gentle 
medications to surgery based on severity. stretching and traction therapy, but 
professional guidance is essential.
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