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(Tapentadol – Tapal – Nucynta) 
Tablets
What is Tapentadol (Aspadol) 100mg?
• Tapentadol is the main active ingredient inside Aspadol 100mg that is a centrally acting 
opioid agonist. This is a narcotic drug. 
• Tapentadol works by altering the pain sensation felt by the body by interacting with the 
neurotransmitters in the brain. It changes how the nervous system and the brain perceive 
pain.
• The effects of Tapentadol occur within 30 minutes of its administration in the body. Its 
effects can last up to 4-6 hours. It is among the most sought after pain management drugs 
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How does Aspadol 100mg Work?
• Aspadol 100mg works by activating the mu-opioid receptor and 
inhibiting the reuptake of naturally occurring chemical norepinephrine 
in the body. 
• It increases levels of extracellular norepinephrine (NE). It binds to the 
mu-opioid receptors particularly and increases the level of 
noradrenaline (NA), thereby leading to analgesia. A person feels little to 
no pain after the analgesia occurs, causing temporary relief. 
• Aspadol 100 mg absorbed and distributed widely throughout the body 
for the best satisfactory results.
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