Evertor 10mg
                     Evertor 10mg - Everolimus Biocon Tablets 
Uses, Dose, Side Effects, Price india
MILLION HEALTH 
PHARMACEUTICALS
Drug profile
• Evertor 10mg containing an active ingredient 
known as Everolimus which is intercedes with 
cancer cell growth and slows down its process.
Evertor 10mg tablets are not used as curable 
medicine, which is used to slow their spreading 
in to the body.
Trade name: Evertor
Active component: 
Everolimus
Strength: 10MG
Mfg: Biocon
Pack: 10 tablets in a strip
Category: Anti-neoplastic 
drug
PRODUCT DETAILS 
Evertor prescribing information
• Evertor tablets are mainly indicated in
Renal carcinoma
Breast carcinoma
Brain carcinoma
Everolimus is also used in various advanced 
stage cancer in stomach, intestines or pancreas.
Evertor mechanism
• Everolimus is an mTOR prohibitor, binds at high 
compatibility to FK506 binding protein 12, 
through producing drug complex that prohibits 
the effective of mTOR.
• This prohibition decrease the activity of effectors 
downstream, which may causes blockage of cell 
progression from G1 into S phase, subsequently 
causes cell growth arrest and apoptosis
Absorption
• The peak plasma concentration time of 
Everolimus reaches within 1 to 2 hours.
The effect of food with Evertor is given below;
With heavy meal: Reduction of systemic 
exposure to Evertor 10mg, and the peak blood 
plasma concentration by 54%.
Distribution
• The blood plasma ratio of Evertor 10mg tablet 
with the range of 5 to 5000ng/ml is 17% to 73%.
Evertor 10mg  human plasma protein bound 
with the range of 74%.
Metabolism
• The metabolism of Everolimus is occurred in 
liver, which is a substrate of CYP3A4.
The metabolites of Everolimus;
Three monohydroxylated metabolite,
Two hydrolytic rings opened products, &
Phosphatidylcholine conjugate of Everolimus.
Excretion
• The terminal half life period of Everolimus is relatively 30 
hours
The major route of elimination
5% in urine; the parent compound has been detected in 
urine or feces.
When to take the drug Evertor 10mg
Evertor 10mg tablets should be administered with or 
without food.
Dosage regimen of Evertor
• In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine 
cancer:
The recommended dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The recommended dosage of Evertor 10mg is 4.5mg/m2 orally as a 
single dose.
In pediatric:
The usual pediatric dosage of Evertor 10mg tablet in brain or 
intracranial tumor is 4.5mg/m2 should be taken orally as a single dose. 
Evertor caused side effects
• Hypersensitivity reactions
Lymphomas & other malignancy
Serious infections
Kidney graft thrombosis
Hepatic artery thrombosis
Nephrotoxicity
Hyperlipemia
Angioedema
Interstitial lung disease
Thrombocytopenia
Male infertility
Proteinuria
      New commencement of diabetes
Drug – Drug interaction
• Evertor 10mg is metabolized hepatically, a substrate of CYP3A4.
Evertor combined with strong inhibitor of CYP3A4, or P-gp, leads to cause decreasing 
the efflux of Everolimus and increase the plasma concentration of Everolimus.
Evertor with strong CYP3A4 inducers, causes increasing the exposure of Everolimus.
Co administration of Evertor 10mg tablet with cyclosporine causes increasing the 
AUC level of Everolimus frequently.
Evertor tablet is combined with ketaconazole or other CYP3A4 inhibitors causes 
increasing the plasma concentration and AUC of Everolimus.
Concomitant of Evertor with erythromycin causes increasing in AUC of Everolimus.
Drug – Drug interaction
• Co administration of Evertor with verapamil leads to increasing the 
plasma concentration of Everolimus.
Co administration of Evertor with Atorvastatin or pravastatin causes 
rhabdomyolysis, due ti increasing concentration of lipid lowering 
agents.
Evertor 10mg with rifampicin causes decreasing the AUC of 
Everolimus
Moderate inhibitors of CYP3A4 & P-gp coadminstered with Evertor 
leads to cause increasing the plasma concentration of Everolimus.
Octreotide is co administered with Evertor 10mg tablet causes 
increasing the Cmin value of Octreotide.
Food drug interaction
• Grape fruit juice may elevate the blood levels 
and effect of Everolimus.
Patients, who are receiving Evertor 10mg 
therapy, should not intake the grape fruit or 
grape fruit juice.
Orange fruit is not conventionally to interact.
Possible contraindication
• Some anaphylactic reaction occurs, if patients 
are contraindicated to the components present 
in the Evertor tablets.
Safety measures
• Lymphomas
Increased exposure of skin cancers, patient may protect from UV light
Serious infections
Patients receiving Evertor have high risk of acquiring various infections 
related to bacteria, virus, and fungi.
Anti-microbial agents are preferred for the suspected patients.
Hepatic artery thrombosis
In liver transplant patients, Evertor therapy should not be recommended.
Nephrotoxicity
• Renal function should be monitored frequently; 
caution should be taken while using Evertor in 
renal impaired patients.
Angioedema
• This may occurred in the patients receiving 
concomitantly Evertor 10mg with Angiotensin 
converting enzyme agents
Hyperlipidaemia
• Patient getting Evertor with lipid lowering drugs causes increasing in plasma 
concentration of these drugs causes hyperlipidaemia
Interstitial lung disease: Occurred in Evertor therapy
Thrombocytopenia: Using Evertor 10mg tablet with cyclosporine causes 
thrombocytopenia
Outbreak of diabetes: Blood glucose level should be monitored
Embryo fetal toxicity: Causes fetal damage using Evertor in pregnancy condition
Immunization: Using live vaccines in Evertor 10mg therapy
Pregnancy and lactation
• Pregnancy category of Everolimus C
Evertor is used only by the patients after 
knowing the benefits to the mother outweighs 
the risk to fetus.
Breast feeding should not be suggested
Storage and handling
• Evertor 10mg tablet should be kept at 25oC
Keep the tablet away from moisture, heat and 
light
Missed dose
• In case of missed dose, patients must consult 
with medical practitioner and follow the 
instructions given by them.
On the other hand the missed dose should be 
avoid and follow the regular dosing schedule.
Over dosage
• The over dosage of Everolimus is rarely occur, in 
case of over dosage patient must be provide with 
supportive measures. The acute toxicity of 
Everolimus over dosage should be monitored.
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