Mabtas RA 500mg injection
                     Mabtas RA 500mg injection 
| Rituximab | Millionpharma
MILLION HEALTH PHARMACEUTICALS
DESCRIPTION
Mabtas RA 500mg is an anticancer 
medicine which prevents the growth 
and spread of cancer cells in the body. 
Mabtas RA 500mg injection also 
indicated for the treatment of Non- 
Hodgkin’s lymphoma or chronic 
lymphocytic and with combination with 
another anticancer drugs like 
methotrexate is used for rheumatoid 
arthritis symptoms in adult treatment. 
INDICATION
Mabtas RA 500mg and hyaluronidase human 
injection are given alone or combination with 
other drugs to treat certain types of non-
Hodgkin's lymphoma and chronic 
lymphocytic leukemia (cancer start in WBC).
Mabtas RA 500mg injection is also used with 
methotrexate (Otrexup, Rasuvo, Xatmep, 
others) for the treatment rheumatoid arthritis 
symptoms in adults that have been already 
treated with some type of regimenknown as 
tumor necrosis factor (TNF) inhibitor. 
CHRONIC LYMPHOCYTIC 
LEUKEMIA
MECHANISM OF ACTION
Mabtas RA 500mg is a type of 
class called as monoclonal 
antibody and which is a new type 
of "targeted" cancer treatment 
and an integral part of the body's 
immune system. 
Mabtas RA 500mg injection works 
by linking to the CD20 antigen on 
normal and malignant B-cells.
Brand : Mabtas 
RA
Ingredients : 
Rituximab 
Strength : 
500mg 
Manufactured : 
Intas 
pharmaceuticals 
ltd
Package : 
injection
DPREOTADIULSCT 
PHARMACOKINETICS
ABSORPTION
Not available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Mabtas RA 500mg metabolized by human antimurine 
antibody production.
EXCRETION
not available
  The half-life of NHL is 22 days and for RA is 18.0            
  days, GPA and microscopic polyangiitis is 23 days
DOSAGE MANAGEMENT
Mabtas RA 500mg injection is 
recommended to administer only through 
intravenous infusion not by IV push or 
bolus.
ADMINISTRTION
    Take an Mabtas RA 500mg injection 
amount and diluted to final concentration of 
1 mg/ml up to 4 mg/ml as infusion 
(containing either 0.9% Nacl or 5% dextrose 
in water). Invert gently the bag and mix the 
solution. Dispose unused drug left in vial.
PRECAUTIONS
Allergic condition against Mabtas RA 500mg
 or any other medication informs your 
doctor.
While using Mabtas RA 500mg injection do 
not take any vaccination or immunization 
without taking advice from doctors.
It is unknown whether Mabtas
 RA 500mg injection passes into breast milk, 
avoid breast-feed while on Mabtas
 RA 500mg treatment.
SIDE EFFECTS
Common effects:
fever and chills (flu like 
symptoms)
Less common side effects:
Weakness; nausea; headache; 
cough; dyspnea; pharyngitis
DRUG INTERACTION
Mabtas RA 500mg injection drug 
interaction has limited data is 
available at present.
Combination with fludarabine or 
cyclophosphamide has no effects in 
pharmacokinetics in CLL patients.
Combination with methotrexate had 
no effects in pharmacokinetics.
CONTRAINDICATIONS
Hypersensitivity or murine 
proteins.
Active severe infections in 
rheumatoid arthritis
Uncontrolled cardiac disease.
PREGNANCY
• Category C: animal studies 
reproduction shown an adverse 
effect on the fetus. The drug has 
no enoughand well controlled 
studies in humans, using in 
pregnant women benefits by 
warrant use of the drug.
LACTATION
Mabtas RA 500mg excreted into 
human milk is unknown. Due to 
the drug belongs to large protein 
molecule, no information is 
available. Women should not 
breast feed during Mabtas RA 
500mg treatment and 12 months 
following last dose.
STORAGE
• Store at 20°C – 30°C
• Use the drug before expiry date
• Protected from direct sunlight
• Do not freeze or shake.
• Keep away from the children’s
• Discard the unused drug by 
asking the advice from doctor or 
pharmacist.
MISSED DOSE
Mabtas RA 500mg injection
 excreted into human milk is 
unknown. Due to the drug 
belongs to large protein 
molecule, no information is 
available. Women should not 
breast feed during Mabtas RA 
500mg treatment and 12 months 
following last dose.
OVERDOSAGE
If the patients had high dose of 
Mabtas RA 500mg then seek 
immediately to the emergency 
department or poison control 
help line. Please consult the 
doctor for further clarification.
CONTACT US 
PHONE NO 
   +91-9940472902
EMAIL  
[email protected]
WEBSITE URL      https
://millionpharma.com/mabtas-ra-500mg.p
hp