Rituxirel 500mg Injection
                     Rituxirel 500mg Injection| Rituximab Uses & 
Side effects
MILLION HEALTH PHARMACEUTICALS
DESCRIPTION
 Rituxirel 500mg is an anticancer medicine 
which prevents the growth and spread of 
cancer cells in the body.
  Rituxirel 500mg injection also indicated for 
the treatment of Non- Hodgkin’s lymphoma or 
chronic lymphocytic and with combination 
with another anticancer drugs like 
methotrexate is used for rheumatoid arthritis 
symptoms in adult treatment
 Rituxirel 500mg with steroid regimen 
combination is given for the treatment of 
some rare disorders which cause blood 
vessels and other tissues inflammation in the 
body.
INDICATION
 Rituxirel 500mg and hyaluronidase human 
injection are given alone or combination with 
other drugs to treat certain types of non-
Hodgkin's lymphoma and chronic lymphocytic 
leukemia (cancer start in WBC).
 Rituxirel 500mg injection is also used with 
methotrexate (Otrexup, Rasuvo, Xatmep, 
others) for the treatment rheumatoid arthritis 
symptoms in adults that have been already 
treated with some type of regimen known as 
tumor necrosis factor (TNF) inhibitor. 

MECHANISM OF ACTION
 Rituxirel 500mg injection is a type of class 
called as monoclonal antibody and which is a 
new type of "targeted" cancer treatment and 
an integral part of the body's immune 
system. 
 Rituxirel 500mg works by linking to the CD20 
antigen on normal and malignant B-cells. 
Hence the body's essential immune security is 
initiated to attack and kill the marked B-cells.
 RITUXIREL 500mg PRODUCT 
DETAILS
Brand : Rituxirel 
Ingredients : 
Rituximab 
Strength : 500mg 
Manufactured : 
Reliance Life 
sciences
Package : 100mg in 
a 1vial
PHARMACOKINETICS
 ABSORPTION
Not available
DISTRIBUTION
volume of distribution is 3.1 L
METABOLISM
Rituxirel 500mg metabolized by human antimurine 
antibody production.
EXCRETION
Not available
The half-life of NHL is 22 days and for RA is 18.0 
days, GPA and microscopic polyangiitis is 23 days.
DOSAGE MANAGEMENT
 Rituxirel 500mg injection is recommended to 
administer only through intravenous infusion 
not by IV push or bolus.
 ADMINISTRTION :
Take an Rituxirel 500mg injection amount and 
diluted to final concentration of 1 mg/ml up to 
4 mg/ml as infusion (containing either 0.9% 
Nacl or 5% dextrose in water). Invert gently 
the bag and mix the solution. Dispose unused 
drug left in vial.
PRECAUTIONS
 Allergic condition against Rituxirel 500mg or 
any other medication informs your doctor.
 While using Rituxirel 500mg injection do not 
take any vaccination or immunization without 
taking advice from doctors.
 Avoid use of Rituxirel 500mg if you are 
pregnant. It will harm the baby unborn, while 
using Rituxirel 500mg use correct birth control 
to prevent pregnancy and for at least 2 weeks 
after your treatment ends. Rituxirel 100mg may 
affect the ability to have children in women. 
Inform your doctor if you planning to pregnant.
SIDE EFFECTS
 Common effects:
fever and chills (flu like symptoms)
 Less common side effects:
Weakness; nausea; headache; cough; 
dyspnea; pharyngitis
DRUG INTERACTION
 Rituxirel 500mg injection drug interaction has 
limited data is available at present.
 Combination with fludarabine or 
cyclophosphamide has no effects in 
pharmacokinetics in CLL patients.
Combination with methotrexate had no effects 
in pharmacokinetics.
CONTRAINDICATIONS
 Hypersensitivity or murine proteins. Active 
severe infections in rheumatoid arthritis 
Uncontrolled cardiac disease.
PREGNANCY
 Category C: animal studies reproduction 
shown an adverse effect on the fetus. The 
drug has no enough and well controlled 
studies in humans, using in pregnant women 
benefits by warrant use of the drug.
LACTATION
 Rituxirel 500mg excreted into human milk is 
unknown. Due to the drug belongs to large 
protein molecule, no information is available. 
Women should not breast feed during Rituxirel
 500mg injection treatment and 12 months 
following last dose.
STORAGE
 • Store at 20°C – 30°C
• Use the drug before expiry date
• Protected from direct sunlight
• Do not freeze or shake.
• Keep away from the children’s
• Discard the unused drug by asking the 
advice from doctor or pharmacist.
MISSED DOSE
 If a dose missed to take at the time then have 
it suddenly before next dose timing, if time 
reach for next dose, then skip missed dose 
and continue and continue the regular 
schedule. Do not have 2 doses at a same 
time.
OVERDOSAGE
 If the patients had high dose of Rituxirel
 500mg then seek immediately to the 
emergency department or poison control help 
line. Please consult the doctor for further 
clarification.
CONTACT US
 EMAIL 
ID : [email protected]
 PHONE NO : +91-9940472902
 WEBSITE URL : 
https://millionpharma.com/rituxirel-500mg.ph
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