xovoltib 20mg
                     Xovoltib 20mg tablet| 
Afatinib Uses & Side 
effects
MILLION HEALTH 
PHARMACEUTICALS
DESCRIPTION
 This is a Phase 2 trial examine the performance of 
a targeted cancer drug known as Xovoltib 20mg. 
Xovoltib 20mg tablets prohibits the EGFR protein, 
which is accepting to be included in driving the 
growth of chordoma tumors.
 This study is plan specifically for chordoma 
patients 18 years or older with recurrent or 
metastatic tumors.
Xovoltib 20mg which is used as prescription drugs 
under the guidance of oncologist physician.
MECHANISM OF ACTION
 Afatinib mechanism by preventing the 
activity of a group of proteins knowns as 
epidermal growth factor receptors (EGFR). 
 Epidermal growth factor receptor is a 
protein which is included in the growth 
and spread of cancer cells; Afatinib works 
by inhibiting the action of this protein.
 Afatinib should not be taken by people 
who having EGFR-negative tumors.
PRODUCT DETAILS
Brand : Xovoltib 
Ingredients : Afatinib 
Strength : 20mg 
Manufactured : GSK pharmaceuticals 
Package : 7 tablets in a strip
PHARMACOKINETICS
 • Time to peak plasma time is 2-5 hr 
and bioavailability are 92 %
• Human plasma protein bound is 95%
• The major circulating metabolites are 
covalent adducts to proteins.
• The drug excretion through feces is 
85% and urine 4% • Half-life is 37 hr.
DOSAGE MANAGEMENT
 For adult: 40mg taken once per day is the prescribed dose for adult 
patients with metastatic non-small cell lung cancer Age of 0-17 
years prescribed dose is not being studied in children.
Avoid using of Xovoltib 20mg tablets drug under 18 years of age
The prescribed dose for renal impairment is given 30mg taken once 
per day
Administration :
Administer the drug Xovoltib 20mg on an empty stomach.
Take the drug Xovoltib 20mg tablets 1 hour before or 2 hours after 
a meal 
Avoid cutting or crushing the tablet
Overdosage : Overdose is reported in patients whom ingested 
360mg ofXovoltib 20mg which causes in nausea, vomiting, 
asthenia, abdominal pain and hence provided supportive 
measurement for recovery.
PRECAUTIONS
 Serious dehydration can occur with the use of Xovoltib 20mg tablets. 
This may be leads to serious or persistent diarrhea, vomiting, or reduced 
fluid intake. Dehydration can result in kidney failure, if it is severe 
enough. While on treatment with this medication, you may be 
encouraged to drink extra water.
During treatment with Xovoltib 20mg will result in hepatotoxicity; 
monitor with periodic liver testing; withhold or stoptreatment for serious 
or worsening liver tests
The drug may result in Interstitial lung disease (ILD)
when administrated to pregnant women, Xovoltib 20mg tablets will have 
foetus harm (embryo-fetal toxicity)
Discontinue the drug,if patients confirm with suspected keratitis or 
ulcerative keratitis 

SIDE EFFECTS
 Common side effects caused :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other 
signs of infection around your fingernails or 
toenails
SIDE EFFECTS
 Serious side effects :
• Eye problems – blurred vision, watery eyes, increased 
sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem 
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins
DRUG INTERACTION
 Co administration of Xovoltib 20mg 
with P-gp inhibitors (cyclosporine A, 
ketoconazole verapamil) will have high 
exposure to Afatinib
When interaction of Xovoltib
 20mg tablets with P-gp inducers 
(carbamazepine, phenytoin, 
phenobarbital) will lowers the exposure 
to Afatinib
MISSED DOSE
 If patient missed to take the dose of 
Xovoltib 20mg, then the missed dose 
must be skipped and follow the regular 
dosing schedule. Do not administer 
double the dose Consult with doctor 
and follow the suggestions.
PREGNANCY
 Pregnancy category: c
During treatment with Xovoltib
 20mg tablets Pregnancy should avoid 
because the drug 
 Xovoltib 20mg is administrated to a 
pregnant woman will harm the foetus.
LACTATION
 Xovoltib 20mg tablets Excretion into 
human milk is unknown or will have 
adverse reaction in a child who is 
breastfed. Hence decision can take 
whether to stop breastfeeding or 
discontinuation of medicine.
STORAGE
 • Xovoltib 20mg Store at 25°C
• Keep Xovoltib 20mg tablets away 
from children
• Protect away free from moisture and 
light.
CONTACT US 
 EMAIL ID 
[email protected]
 PHONE NO 
 +91-9940472902
 WEBSITEURL  
 https
://millionpharma.com/xovoltib-20mg.php