Xovoltib 30mg
                     XOVOLTIB 30MG TABLET| 
AFATINIB USES & SIDE 
EFFECTS
MILLION HEALTH PHARMACEUTICALS
DESCRIPTION
• This is a Phase 2 trial examine the performance of a 
targeted cancer drug known as Xovoltib 30mg. 
• Xovoltib 30mg tablets prohibits the EGFR protein, which is 
accepting to be included in driving the growth of 
chordoma tumors.
• This study is plan specifically for chordoma patients 18 
years or older with recurrent or metastatic tumors.
Xovoltib 30mg which is used as prescription drugs under 
the guidance of oncologist physician.
INDICATION
• Xovoltib 30mg tablets is used for the first-line treatment 
for patients with metastatic non-small cell lung 
cancer(NSCLC)

MECHANISM OF ACTION
• Afatinib mechanism by preventing the activity of a group 
of proteins knowns as epidermal growth factor receptors 
(EGFR).
•  Epidermal growth factor receptor is a protein which is 
included in the growth and spread of cancer cells; Afatinib 
works by inhibiting the action of this protein.
• Afatinib should not be taken by people who having EGFR-
negative tumors.
PRODUCT 
DETAILS
Brand : Xovoltib 
Ingredients : 
Afatinib 
Strength : 30mg 
Manufactured : 
GSK 
pharmaceuticals 
Package : 7 
tablets in a strip
PHARMACOKINETICS
• Time to peak plasma time is 2-5 hr and bioavailability are 
92 %
• Human plasma protein bound is 95%
• The major circulating metabolites are covalent adducts to 
proteins.
• The drug excretion through feces is 85% and urine 4% • 
Half-life is 37 hr.
DOSAGE MANAGEMENT
• For adult: 40mg taken once per day is the prescribed 
dose for adult patients with metastatic non-small cell lung 
cancer Age of 0-17 years prescribed dose is not being 
studied in children.
• Avoid using of Xovoltib 40mg tablets drug under 18 years 
of age
• The prescribed dose for renal impairment is given 30mg 
taken once per day
ADMINISTRATION
• Administer the drug Xovoltib 30mg tablets on an empty 
stomach.Take the drug Xovoltib 30mg1 hour before or 2 
hours after a meal Avoid cutting or crushing the tablet
• Overdosage: Overdose is reported in patients whom 
ingested 360mg of Xovoltib 30mg tablets which causes in 
nausea, vomiting, asthenia, abdominal pain and hence 
provided supportive measurement for recovery.
PRECAUTIONS
• Serious dehydration can occur with the use of Xovoltib 30mg . This may be 
leads to serious or persistent diarrhea, vomiting, or reduced fluid intake. 
Dehydration can result in kidney failure, if it is severe enough. While on 
treatment with this medication, you may be encouraged to drink extra water.
• The drug may result in Interstitial lung disease (ILD)
when administrated to pregnant women, Xovoltib 30mg will have foetus 
harm (embryo-fetal toxicity)
Discontinue the drug,if patients confirm with suspected keratitis or 
ulcerative keratitis 
With Xovoltib 30mg tablets have increased sunburn/phototoxicity; may 
aggravate rash or acne; patients use with caution to limit sun exposure and 
where sunscreen and protective clothing.
• sometimes, Xovoltib 30mg has been bind to corneal perforation, a serious 
injury to the part of the eye which focuses light into the eye. If you have any 
persistent eye pain or changes in vision, inform your doctor immediately.
SIDE EFFECTS
• Common side effects caused :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other signs of 
infection around your fingernails or toenails
SIDE EFFECTS
• Serious side effects :
• Eye problems – blurred vision, watery eyes, increased 
sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem 
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins
DRUG INTERACTION
• Co administration of Xovoltib 30mg tablets with P-gp 
inhibitors (cyclosporine A, ketoconazole verapamil) will 
have high exposure to Afatinib
When interaction of Xovoltib 30mg with P-gp inducers 
(carbamazepine, phenytoin, phenobarbital) will lowers the 
exposure to Afatinib
MISSED DOSE
• If patient missed to take the dose of Xovoltib 30mg tablets
, then the missed dose must be skipped and follow the 
regular dosing schedule. Do not administerdouble the 
dose
Consult with doctor and follow the suggestions.
PREGNANCY
• Pregnancy category: c
During treatment with Xovoltib 30mg Pregnancy should 
avoid because the drug 
• Xovoltib 30mg tablets is administrated to a pregnant 
woman will harm the foetus.
LACTATION
Xovoltib 30mg Excretion into human milk is unknown or will 
have adverse reaction in a child who is breastfed. Hence 
decision can take whether to stop breastfeeding or 
discontinuation of medicine.
STORAGE
• Xovoltib 30mg tablets Store at 25°C
• Keep Xovoltib 30mg away from children
• Protect away free from moisture and light.
CONTACT US 
EMAIL ID : [email protected]
PHONE NO : +91-9940472902
WEBSITE URL : 
https://millionpharma.com/xovoltib-30mg.php