Xovoltib 40mg tablet
                     XOVOLTIB 40MG TABLET| 
AFATINIB USES & SIDE 
EFFECTS | MHP
MILLION HEALTH PHAMACEUTICALS
DESCRIPTION
 This is a Phase 2 trial examine the performance 
of a targeted cancer drug known as Xovoltib
 40mg.
 Xovoltib 40mg tablet prohibits the EGFR protein, 
which is accepting to be included in driving the 
growth of chordoma tumors.This study is plan 
specifically for chordoma patients 18 years or 
older with recurrent or metastatic tumors. 
 Xovoltib 40mg which is used as prescription 
drugs under the guidance of oncologist 
physician.
INDICATION
 Xovoltib 40mg tablet is used for the first-
line treatment for patients with 
metastatic non-small cell lung 
cancer(NSCLC)
Metastatic non-small cell lung 
cancer(NSCLC)
MECHANISM OF ACTION
 Afatinib mechanism by preventing the 
activity of a group of proteins knowns as 
epidermal growth factor receptors 
(EGFR). Epidermal growth factor receptor 
is a protein which is included in the 
growth and spread of cancer cells; 
Afatinib works by inhibiting the action of 
this protein.
 Afatinib should not be taken by people 
who having EGFR-negative tumors.
PRODUCT DETAILS
Brand : Xovoltib
 Ingredients : Afatinib
Strength : 40mg
Manufactured : GSK 
pharmaceuticals
Package : 7 tablets in a strip 

PHARMACOKINETICS
 • Time to peak plasma time is 2-5 hr and 
bioavailability are 92 %
 • Human plasma protein bound is 95%
 • The major circulating metabolites are 
covalent adducts to proteins.
 • The drug excretion through feces is 
85% and urine 4% • Half-life is 37 hr.
DOSAGE MANAGEMENT
 For adult: 40mg taken once per day is the prescribed dose for 
adult patients with metastatic non-small cell lung cancer Age of 
0-17 years prescribed dose is not being studied in children.
 Avoid using of Xovoltib drug under 18 years of age
 The prescribed dose for renal impairment is given 30mg taken 
once per day
 Administration :
 Administer the drug Xovoltib on an empty stomach.
 Take the drug Xovoltib 1 hour before or 2 hours after a meal
 Avoid cutting or crushing the tablet
 Overdosage : Overdose is reported in patients whom ingested 
360mg of Xovoltib which causes in nausea, vomiting, asthenia, 
abdominal pain and hence provided supportive measurement for 
recovery.
PRECAUTIONS
 Serious dehydration can occur with the use of Xovoltib
 40mg . This may be leads to serious or persistent diarrhea, 
vomiting, or reduced fluid intake. Dehydration can result in 
kidney failure, if it is severe enough. While on treatment 
with this medication, you may be encouraged to drink extra 
water.
 During treatment with Xovoltib 40mg tablet will result in 
hepatotoxicity; monitor with periodic liver testing; withhold 
or stoptreatment for serious or worsening liver tests.The 
drug may result in Interstitial lung disease (ILD).
  sometimes, Xovoltib 40mg has been bind to corneal 
perforation, a serious injury to the part of the eye which 
focuses light into the eye. If you have any persistent eye 
pain or changes in vision, inform your doctor immediately.
SIDE EFFECTS
 Common side effects caused :
 • Mild diarrhae for 1 day or less
 • Decreased appetite
 • Nausea and vomiting
 • Mouth ulcer
 • Acne, itching, dry skin
 • Red colour, tenderness, swelling or 
other signs of infection around your 
fingernails or toenails
SIDE EFFECTS
 Serious side effects :
 • Eye problems – blurred vision, watery eyes, increased 
sensitivity to light
 • Liver problem – stomach pain, feeling tried, dark urine
 • Heart problem
 • Urine colour changes to dark
 • Bleeding or bruising
 • Weakness
 • Blurred vision
 • Rapid heartbeat
 • Breathing trouble
 • Cough and fever
 • Yellowing the skins
DRUG INTERACTION
 Co administration of Xovoltib 40mg with 
P-gp inhibitors (cyclosporine A, 
ketoconazole verapamil) will have high 
exposure to Afatinib
 When interaction of Xovoltib 40mg tablet
 with P-gp inducers (carbamazepine, 
phenytoin, phenobarbital) will lowers the 
exposure to Afatinib
MISSED DOSE
 If patient missed to take the dose of 
Xovoltib 40mg, then the missed dose 
must be skipped and follow the regular 
dosing schedule. Do not 
administerdouble the dose
 Consult with doctor and follow the 
suggestions.
PREGNANCY
 Pregnancy category: c
 During treatment with Xovoltib
 40mg tablet Pregnancy should avoid 
because the drug Xovoltib 40mg is 
administrated to a pregnant woman will 
harm the foetus.
LACTATION
 Xovoltib 40mg Excretion into human milk 
is unknown or will have adverse reaction 
in a child who is breastfed. Hence 
decision can take whether to stop 
breastfeeding or discontinuation of 
medicine.
STORAGE
 • Xovoltib 40mg tablet Store at 25°C
 • Keep Xovoltib 40mg away from 
children
 • Protect away free from moisture and 
light.
CONTACT US
 PHONE NO : +91-9940472902
 EMAIL 
ID : millionhealthpharmaceuticals@gmail
.com
 WEBSITE URL: 
https://millionpharma.com/xovoltib-40m
g.php