Xovoltib 50mg tablet
                     XOVOLTIB 50MG TABLET| 
AFATINIB USES & SIDE EFFECTS
M I L L I O N  H E A LT H  P H A R M AC E U T I C A L S
DESCRIPTION
• This is a Phase 2 trial examine the performance of 
a targeted cancer drug known as Xovoltib 50mg. 
Xovoltib 50mg tablets prohibits the EGFR protein, 
which is accepting to be included in driving the 
growth of chordoma tumors.
This study is plan specifically for chordoma 
patients 18 years or older with recurrent or 
metastatic tumors.
Xovoltib 50mg which is used as prescription drugs 
under the guidance of oncologist physician.
INDICATION
• Xovoltib 50mg tablets is used for the first-line 
treatment for patients with metastatic non-small 
cell lung cancer(NSCLC)
   LUNG CANCER
MECHANISM OF ACTION
• Afatinib mechanism by preventing the activity of 
a group of proteins knowns as epidermal growth 
factor receptors (EGFR). Epidermal growth factor 
receptor is a protein which is included in the 
growth and spread of cancer cells; Afatinib works 
by inhibiting the action of this protein.
Afatinib should not be taken by people who 
having EGFR-negative tumors.
PRODUCT 
DETAILS
Brand : Xovoltib 
Ingredients : 
Afatinib 
Strength : 50mg 
Manufactured : GSK 
pharmaceuticals Pac
kage : 7 tablets in a 
strip
PHARMACOKINETICS
• Time to peak plasma time is 2-5 hr and 
bioavailability are 92 %
• Human plasma protein bound is 95%
• The major circulating metabolites are covalent 
adducts to proteins.
• The drug excretion through feces is 85% and 
urine 4% • Half-life is 37 hr.
DOSAGE MANAGEMENT
• For adult: 40mg taken once per day is the prescribed dose for 
adult patients with metastatic non-small cell lung cancer Age of 
0-17 years prescribed dose is not being studied in children.
Avoid using of Xovoltib drug under 18 years of age
The prescribed dose for renal impairment is given 30mg taken 
once per day
• Administration :
Administer the drug Xovoltib 50mg on an empty stomach.
Take the drug Xovoltib 50mg tablets 1 hour before or 2 hours 
after a meal 
Avoid cutting or crushing the tablet
Overdosage : Overdose is reported in patients whom ingested 
360mg of Xovoltib 50mg which causes in nausea, vomiting, 
asthenia, abdominal pain and hence provided supportive 
measurement for recovery.
PRECAUTIONS
• Serious dehydration can occur with the use of Xovoltib 50mg tablets. 
This may be leads to serious or persistent diarrhea, vomiting, or 
reduced fluid intake. Dehydration can result in kidney failure, if it is 
severe enough. 
• While on treatment with this medication, you may be encouraged to 
drink extra water.
During treatment with Xovoltib 50mg will result in hepatotoxicity; 
monitor with periodic liver testing; withhold or stoptreatment for 
serious or worsening liver tests
• The drug may result in Interstitial lung disease (ILD)
sometimes, Xovoltib 50mg tablets has been bind to corneal 
perforation, a serious injury to the part of the eye which focuses light 
into the eye. If you have any persistent eye pain or changes in vision, 
inform your doctor immediately.
SIDE EFFECTS
• Common side effects caused :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other signs 
of infection around your fingernails or toenails
SIDE EFFECTS
• Serious side effects :
• Eye problems – blurred vision, watery eyes, increased 
sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem 
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins
DRUG INTERACTION
• Co administration of Xovoltib 50mg with P-gp 
inhibitors (cyclosporine A, ketoconazole 
verapamil) will have high exposure to Afatinib
When interaction of Xovoltib 50mg tablets with P-
gp inducers (carbamazepine, phenytoin, 
phenobarbital) will lowers the exposure to 
Afatinib
MISSED DOSE
• If patient missed to take the dose of Xovoltib
 50mg, then the missed dose must be skipped 
and follow the regular dosing schedule. Do not 
administer double the dose
Consult with doctor and follow the suggestions.
PREGNANCY
• Pregnancy category: c
During treatment with Xovoltib 50mg tablets 
Pregnancy should avoid because the drug 
• Xovoltib 50mg is administrated to a pregnant 
woman will harm the foetus.
LACTATION
• Xovoltib 50mg tablets Excretion into human milk 
is unknown or will have adverse reaction in a 
child who is breastfed. Hence decision can take 
whether to stop breastfeeding or discontinuation 
of medicine.
STORAGE
• Xovoltib 50mg Store at 25°C
• Keep Xovoltib 50mg tablets away from children
• Protect away free from moisture and light.
CONTACT US 
• EMAIL 
ID: [email protected]
• PHONE NO : +91-9940472902
• WEBSITE URL : 
https://millionpharma.com/xovoltib-50mg.php