IVF London Brochure


Ivflondon5

Uploaded on Sep 30, 2024

Expert fertility clinic offering personalized care from a dedicated team to support your journey to parenthood with compassion and expertise.

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IVF London Brochure

A message from the founder... IVF London is built on the pillars of science and technology in reproductive medicine. As a scientist and an entrepreneur, I am passionate about our ethos: ‘it’s all about the journey’. Our team pride themselves in living up to this expectation. At IVF London, we elements of holistic therapies and emotional support to aid you in this journey. We believe very strongly in the mind and body balance which is pivotal in the wellbeing of any individual. Our highly experienced consultants are there to provide a very bespoke treatment plan to suit your needs. IVF London is proud to be a fully inclusive clinic that pledges to make your dream of parenthood a reality. It’s the place where dreams are conceived… Mr Alpesh Doshi Clinic Director and Consultant Embryologist 24x7 Embryo Monitoring by Timelapse Technology Supported Embryology Consultants Mr Alpesh Doshi Clinic Director/Consultant Embryologist Dr Arati Rama Rao Dr Baydaa Abdulrah im Consultant Fertility Specialist Consultant Fertility Specialist Dr Pari jat Bha ercharjee Dr C P Lim Consultant Gynaecologist Endometriosis Consultant Dr Anand Saggar Dr Jonathan Katz Consultant Clinical Geneticist Consultant Endocrinologist e Clinic Waiting Are a Zen Ro om Recovery Ward Laborato ry IVF IVF is one of the primary treatments o ered for couples experiencing infertility and is a more involved procedure than IUI as it requires stimulating your ovaries to produce eggs, retrieving your eggs, having an embryologist fertilise them with your partners sperm or donated sperm in a laboratory, followed by close observation of any developing embryos, until the optimum time for transfer which ensures only the best quality embryos are placed back into your uterus so that they can continue growing as with a normal pregnancy. WHY? If you or your partner have been diagnosed with a genetic, anatomical or hormonal fertility problem, you are likely to be o ered IVF treatment as which provides a greater chance of success than other treatments. Your consultant will advise if an IVF treatment pathway is appropriate for you, particularly if you or your partner have been diagnosed with any of the following; Fallopian tube damage or blockage Ovulation disorders including premature ovarian failure Endometriosis Uterine broids Impaired sperm production Unexplained infertility A genetic disorder ICSI Intracytoplasmic Sperm Injection (ICSI) was introduced as a clinical level improvement to conventional IVF treatments. It involves carefully selecting only one single sperm of the best quality for injection into an egg to achieve fertilisation. s procedure is done using a high precision technique called ‘micromanipulation’. e resulting embryo is then transferred back into the uterus to continue its development as with a normal pregnancy. WHY? ICSI is recommended when there is severe male factor infertility, including low sperm concentration, poor motility, blockages in the male reproductive tract or where there is a desire to get pregnant a r having had a vasectomy. It may also be advised when the female has a very low yield of eggs during egg retrieval so as to directly improve the chances of fertilisation by clinical intervention. Your IVF London consultant may also recommend this enhanced procedure if a previous IVF treatment has resulted in a low fertilisation rate of eggs. HOW? e woman will be required to undergo ovarian stimulation to prepare her eggs for collection as in a traditional IVF treatment plan. e sperm from the male partner will then be processed, washed and inspected in our laboratory to select only one sperm which will then be carefully injected into a retrieved egg. e aim is to inject the most normal looking sperm with good progressive movement into each mature egg. In cases of surgically retrieved sperm ICSI or PICSI may be recommended to achieve fertilisation. When is ICSI required? Genetic Testing PGT-A Also known as aneuploidy screening Used to check the number of chromosomes in an embryo. A euploid (normal) embryo should have 23 pairs of chromosomes Enables the selection of a chromosomally normal embryo Next Generation Sequencing (NGS) is used for the testing of the embryos and is one of the most technologically advanced methods of genetic testing PGT-A does not guarantee a chromosomally normal embryo Who would PGT-A be recommended for? Women over the age of 38 Peo ple with a history of repeated implantation failure People with a history of repeated miscarriage Genetic Testing PGT-M Also known as PGD Recommended for couples who have a history of a genetic disease in their family Requires a ‘work-up’ prior to embryo creation to ensure that condition can be tested for Karyomapping used to test for condition Process similar to PGT-A PGT-SR Used in patients where there is a chromosomal structural rearrangement PGT-SR is appropriate for people who have had a child or pregnancy with a chromosomal rearrangement or if you or your partner are a carrier of any one of these three primary types of rearrangements: Reciprocal translocations Robertsonian translocations Inversions Treatments for same-sex couples You will be o ered support from our counselling team prior to any treatment to help you understand the emotional and legal issues in order that you are completely comfortable and con dent with your decision to proceed Our laboratory team will help you nd a suitable donor from our collaborating European, American and UK sperm donor banks. e matching of donors can be done with your speci c requirements If suitable we would always start with the mildest approach to treatment such as Intrauterine Insemination (IUI) using donor sperm. e procedure involves placing donor sperm closer to the egg at the time of ovulation in the hope it is fertilised. In some cases IVF (using donor sperm) may be more appro- priate and o ers a higher chance of pregnancy compared to IUI. Any resulting embryos are then transferred into your uterus to continue development as a pregnancy. If you are in a same-sex relationship and wish one partner to donate her eggs and the other partner to carry the pregnancy then ‘shared motherhood’ is an option that provides both partners the intimate experience of a shared maternal role when starting a family. Treatment for Single women Donor insemination (DI) may be recommended as an e ective treatment for single women who desire a start a family. We will help you get started as a sperm recipient (via donation) process unless you already have a donor in mind. You will begin by reviewing donor pro les which enables you to select which donor may be the best ‘ t’ for you. IVF London only use donors in accordance with stringent HFEA criteria. is means that donated sperm will usually be provided by men between the ages of 18 and 41. Sperm donors will have been required to undertake a series of health tests/screening, including HIV and hepatitis, to ensure that they do not pass on any serious diseases or medical conditions to you or your baby Sperm Donation and the Law: Sperm donor is only able to create 10 families within the UK. e donors identifying information must be given to the HFEA for its con dential register. When a donor-conceived person becomes 18, they are able to contact the HFEA and request the identifying information for their sperm donor Timelapse Imaging ere is a growing body of evidence time-lapse systems have a signi cant positive impact on success rates compared to traditional incubators. ey generate images of the embryos every 10 to 15 minutes, creating a time-lapse video of embryo development. is enables our embryologists to analyse and identify any potential aberrations in embryo development that would be missed when using conventional incubation techniques. is helps us improve embryo selection for transfer, cryopreservation and biopsy. Uninterrupted culture of embryos ensuring stable environment Allows embryologists to analyse every stage of embryo development Provides ‘real-time’ footage of embryos and a continuous overview Allows observation of key events to aid embryo selection for transfer Embryoscope works hand in hand with arti cial intelligent technology to give embryos a quality score Embryo Assist AI IVF London has partnered with Fairtility™ to introduce arti cial intelligence into the laboratory. Embryo Assist AI powered by CHLOE™ (Cultivating Human Life through Optimal Embryos) is a transparent AI-based decision support tool. Embryo Assist AI provides clinicians and patients with visibility into the clinical and laboratory data to help improve IVF outcomes. Patients are able to watch a live feed of their embryos on their phones. e embryologists can then interpret these images for the patients when they receive their embryo updates. e algorithm that powers the AI has been trained on tens of thousands of embryos. e AI starts scoring embryos from day 2 a er fertilisation and provides a running score until blastocyst development. Along with the score, the embryos are also ranked to give embryologists more information on which embryo to select for transfer. Treatment Add-Ons Embryoscop e Allows uninterrupted culture of embryo s Image taken of embryo every 10-15 mins creating time-lapse vide o Enables embryologists to analyse every stage of developme nt Calcium Ionophore Used following ICSI to aid egg activation Indicated in patients that have had previous low or failed fertilisation Can also be used to aid be er blastocyst development is a device, also called a chip, which can be used in the IVF laboratory to prepare and select sperm for insemination by intracytoplasmic sperm injection (ICSI) relies on the sperm actively swimming through the membrane lter in the chip, demonstrating motility PICSI Physiological intracytoplasmic sperm injection Involves placing sperm with hyaluronic acid (HA) Sperm that bind to HA are selected for injection Helps to select mature sperm with be er DNA Treatment Add-Ons EmbryoGlue® Embryo culture media enriched with hyaluronan Hyaluronan acts like a bridge between the embryo and the womb Helps the embryo and womb stick together while reducing how much the embryo can move around Endometrial Scratch Lining of uterus gently scratched using thin catheter Localised ‘injury’ can cause uterus to start ‘repair reaction’ May increase chances of embryo implantation Endometrial Testing (ERA, EMMA, ALICE) Biopsy taken from uterus at time of mock embryo transfer Cells assessed to determine window of implantation (ERA) Results will determine timings for subsequent embryo transfers. EMMA and ALICE tests focus on the microbiology of the endometrium Intralipid Infusion Raised natural killer cell activity can act against embryo implantation Intralipid infusions can help to lower the activity of natural killer cells Can also be used in cases of repeated miscarriage/ implantation failure Initial consultation Treatment Investigations Nurse consultation Pathways Ovarian stimulation Tablets/hormones given to aid follicle growth Ovarian stimulation Ovarian stimulation Implications counselling Implications counselling Surrogate identi ed Egg collection Sperm prepared in lab Egg collection and Egg collection and sperm preparation sperm preparation Donor egg selection Meeting with lawyer Eggs frozen Sperm sample inserted Fertilisation with Fertilisation with Recipient started on egg directly into uterus IVF/ICSI IVF/ICSI recipient cycle Commissioning couple screened Eggs frozen for future use can be stored for up Embryo culture Embryo culture Donor eggs thawed Ovarian stimulation to 55 years with consent being renewed every 10 Egg collection and years Embryo transfer and/or Day 5/6 embryos have embryo freezing 5-7 cells biopsied Sperm prepared in lab sperm preparation Fertilisation with IVF/ICSI Embryos frozen while Fertilisation with waiting for results IVF/ICSI Embryo culture and freezing Cells sent to genetics lab 3-month embryo for testing (~ 2 weeks) Embryo culture quarantine Commissioning couple Normal/una cted Embryo transfer and/or rescreened embryo transferred embryo freezing Surrogate prepared for frozen embryo transfer Embryo transferred into surrogate Egg Freezing Intrauterine IVF/ICSI with Insemination IVF/ICSI Donor Eggs SurrogacyPGT Initial consultation LGBTQ+ Treatment Investigations Pathways Nurse consultation Implications counselling Implications counselling Implications counselling Implications counselling Implications counselling Implications counselling Donor sperm selection Surrogate identi ed Donor sperm selection Donor sperm selection Ovarian stimulation Semen production Partner 1 screened as Meeting with lawyer Tablets/hormones given donor to aid follicle growth Ovarian stimulation Egg collection Sperm freezingOvarian stimulation for Commissioning couple partner 1 screened as donors Sperm prepared in lab Egg collection and sperm preparation Egg collection and Egg freezing Egg donor chosendonor sperm Sperm frozen for future preparation use can be stored for up Eggs thawed and sperm Sperm sample inserted Fertilisation with to 55 years with consent prepared directly into uterus IVF/ICSI Fertilisation with being renewed every 10 IVF/ICSI years. Fertilisation with ICSI Eggs frozen for future (eggs can be split Embryo culture and between male partners Embryo culture use can be stored for upfreezing Please note that spermto 55 years with consent can only be frozen if Embryo culture and freezing Partner 2 prepared for being renewed every 10 hormone replacement Embryo transfer and/or frozen embryo transfer years therapy has not 3-month embryo embryo freezing commenced. quarantine Embryo thawed and transferred Commissioning couple rescreened Surrogate prepared for frozen embryo transfer Embryo transferred into surrogate Intrauterine IVF/ICSI with Shared Insemination with donor sperm Motherhood Female-to-Male Male-to-Female Same-sex Male donor sperm (ROPA) Transition Transition Surrogacy 2022 Statistics 2021 Statistics Price List 2024 Consultations Initial Consultation (required for all treatments. All other consultations below include the £200 £200 charge for the initial consultation) Shared motherhood initial consultation £400 Initial Consultation including Pelvic Scan, AMH Test and Semen Analysis £565 Female Fertility Ultrasound and Diagnostic Tests Fertility Wellness Check £480 Includes: Ultrasound scan, AMH blood test & 30 minutes consultation HyCoSy £450 Male Fertility Assessment and Diagnostic Tests Semen Analysis £150 Sperm DNA Fragmentation £423 Comprehensive Semen Assessment package £599 Treatment Packages Intrauterine Insemination (IUI) £1,100 Stimulated IVF £3,700 Embryo Freezing Cycle £4,400 Required additions: HFEA fee, monitoring blood tests, culture and medication Frozen Embryo Transfer (FET) £2450 Egg Freezing Cycle £3,400 Multicycle Packages Duo-Stim with ICSI £9,200 2 Egg Freezing Cycles £5,950 3 Egg Freezing Cycles £8,540 2 Embryo Freezing Cycles £8,300 3 Embryo Freezing Cycles £11,995 Genetic Testing of Embryos (PGT) PGS Next Generation Sequencing (now called PGT-A) Analysis of up to 4 embryos, includes biopsy fee £2,950 PGT-SR (Robertsonian and Reciprocal Translocations) Analysis of up to 8 embryos, includes biopsy fee £4,250 PGD with Karyomapping £4,950 Embryology and Other Procedures Embryoscope + Add CHLOE - AI £750 Intracytoplasmic Sperm Injection (ICSI) + Add PICSI £200* £1,350 Zymot Micro uidic Sperm Selection £250 Extended Culture £500 Embryo Glue £250 Calcium Ionophore £495 Embryo Freezing – includes rst year of storage £935 Annual Storage Fee £300 Non-Invasive Prenatal Testing – includes pregnancy scan and photo £595 only chromosomes 13, 18, 21 and sex chromosome abnormalities Endometrium Testing Endometrium Receptivity Array (ERA) £1,500 Analysis of Infectios Chronic Endometritis (ALICE) £750 Endometrial Microbiome Metagenomic Analysis (EMMA) – includes ALICE £950 Endome TRIO (ERA, ALICE and EMMA) £1,742 Elstree Site: Central London Satellite: IVF London Basinghall Clinic Caspian House Cromwell Hospital 4 Basinghall Street Elstree Road, EC2V 5BQ Borehamwood WD6 3BS Tel: 020 724 4886 ivf_londonuk IVFLondonUK IVF_londonUK +44 7916 027989 020 8075 8881 / 020 8207 4115