GLP-1 medications (like semaglutide and tirzepatide) are powerful tools, but they work best as part of a bigger picture. It is important to optimize all 6 pillars of lifestyle – nutrition, physical activity, sleep, stress, avoidance of risky substances and connectedness – as neglecting any of them can decrease the drug’s efficacy, worsen side effects and may contribute to weight regain after the medications are discontinued.