An Alternative to Knee Surgery- Regenerative Cellular Therapies
                     An Alternative to Knee Surgery- Regenerative Cellular Therapies
Regenerative cell treatments and PRP may offer an 
unconventional alternative to knee surgery or knee 
replacement.
Medica Stem Cells regenerative treatments are 
minimally invasive non-surgical procedures. Treatments 
provide long-lasting relief from symptoms with minimal 
downtime and enhance recovery within a short period 
using your own body's healing power to treat knee 
arthritis and knee-related injuries. Our patients benefit 
from reduced pain and enhanced functionality of the 
knee without undergoing surgery or knee replacement.
Can Regenerative Therapy Revitalize Your Knee Joint Without Surgery?
Imagine climbing the stairs where your knee catches and buckles with severe ache. What 
happens if you fall unexpectedly and if you are unable to get up? You may not be ready to 
consult a physician as you would have seen your relatives spent more on procedures that did 
not prove to be effective. 
No worries! We are here to help you understand your natural healing mechanism through 
regenerative cellular therapies. It is time to get back to your active life without knee surgery!
Before we go through the potential knee problems and treatment, let us know the anatomy 
and working mechanism of the knee joint.
Knee Joint Anatomy
Knee Joint Anatomy
• The knee joint is composed of bones, tendons, ligaments, cartilage and bursal sac. All these parts 
work with coordination to help us walk, jump, and bend down.
• Bones: There are three types of bones in the knee, namely femur, tibia, and patella. The knee joint 
connects the tibia (shin bone) and the femur (thigh bone), including a protective bony cover named 
patella (kneecap). Femur and tibia end as a rounded protuberance named condyle, which forms the 
part of the knee joint.
• Knee cartilage is otherwise called as the knee meniscus. There are two types of knee meniscus, namely 
medial (inside) and lateral (outside). It is located between the femur and the tibia. It helps in 
distributing the body weight and protects the bones from friction. 
• Tendons connect bone to muscle. There are two types of tendons, namely quadriceps tendon and 
patellar tendon. The quadriceps tendon connects the patella to the large thigh muscle named 
quadriceps muscle. The patellar tendon attaches to the tibia.
• Ligaments hold bones or cartilage together. There are two types of ligaments, namely anterior cruciate 
ligament (ACL) and the posterior cruciate ligament (PCL). ACL lies at the front part of the knee joint 
while PCL lies at the back. They hold femur and tibia together to stabilize the knee joint. 
• Bursa sac consists of lubricating fluid that remains as a cushion between the bones in the knee joint to 
reduce friction. 
The Function of Knee joint
• Imagine a door that opens and closes with the help of a hinge. Similarly, the knee joint is 
considered as a flexible hinge that aids in mobility. You can normally move your leg in front-to-back 
and side-to-side motion. In case of improper joint movement due to worn-out shoes or trauma, 
acute knee injuries may occur. 
• Similarly, the knee is also considered as the weight-bearing joint. It is the knee joint that balances 
a person’s weight. In the case of obesity, excess pressure falls on the knee joint, which may lead to 
cartilage damage, degeneration, or wear and tear.
Common knee joint problems
Knee JointProblems
Knee bursitis Tendonitis Osteoarthritis Torn meniscus Knee ligament 
(Bursa (Tendon (degenerative (cartilage wear tear (ACL/PCL Knee bone spur Fracture/sprained 
Iliotibial band Hamstring 
knee (ITB) syndrome injury (Tear of Other sports-inflammation) inflammation) knee joint and tear) injury)
– Knee pain the tendons or related injuries 
disease)
due to worn- muscles at the such as athlete 
out or poorly back of the injury, football 
fitting shoes thigh) or soccer injury
What are the conventional methods to relieve knee 
pain?
Rest
Activity 
Ice therapy
modification
Elevation Compression
What is the principle of regenerative cell therapy?
• Your body can heal by itself. That is the motto of regenerative cell therapy. Let us see how the 
body heals.
• If you cut your finger, it bleeds. It then forms a scab like structure. Ultimately, it is the healing cell 
beneath the scab that seals the injury and stop the bleeding. Similarly, your body can also 
examine the signs of damage and repair them using its healing cells.      
• Regenerative cell therapy is a non-surgical procedure that provides long-lasting relief from the 
symptoms with minimal downtime and enhances recovery within a short period. It has no side 
effects since the injection involves your blood. So, there is no chance of rejection or cross-
transmission of disease.
Advancement of regenerative therapy over 
conventional methods
• A study published in NPJ Regenerative Medicine revealed that regenerative cell therapy may 
provide better pain relief compared to NSAIDs drugs and corticosteroid injections [1].
• Recent research shows that provides more long-term relief from joint pain and enhances the 
quality of life in a shorter duration compared to corticosteroid injections. People may think that 
PRP injection is just like a cortisone shot. But it is not so. Long-term administration of cortisone 
injections will suppress the body’s natural healing mechanism and leads to knee replacement 
surgery in the future. But PRP therapy repairs the injured tissue by naturally promoting your 
body’s healing function. Hence, you need not have to undergo surgery in your later stage [2].
• Surgery may promote knee degeneration which leads to undergoing the same surgery once again 
in the future. Additionally, the incidence of pain after the surgery is high around 20%, in addition to 
anaesthesia and surgery associated risks. With the advent of PRP therapy, surgery can be easily 
avoided [4].
• So, what are you waiting for? Turn back the clock and start leading an active pain-free life by 
opting for regenerative cell therapy! 
If you feel you may benefit from 
regenerative therapies, please contact 
us at our London clinic on
 020 8 168 2000 or our Ireland clinic on 
01 298 8000 to book a consultation or 
request a callback today! 
We will take a close look at your case 
and evaluate if you are a qualified 
candidate for regenerative therapy.  
References
• Iijima, H., Isho, T., Kuroki, H., Takahashi, M., & Aoyama, T. (2018). Effectiveness of mesenchymal 
stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment 
of effective regenerative rehabilitation. NPJ Regenerative medicine, 3(1), 1-13.
• Forogh B, Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S. Effect of single injection of Platelet-
Rich Plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized 
clinical trial. J Sports Med Phys Fitness. 2015 Jul 14.  [Google Scholar]
• Cooper C, Chapurlat R, Al-Daghri N, et al (2019). Safety of Oral Non-Selective Non-Steroidal Anti-
Inflammatory Drugs in Osteoarthritis: What Does the Literature Say? Drugs Aging. 36(Suppl 1):15–
24. doi:10.1007/s40266-019-00660-1.
• Gautam Das, Debjyoti Dutta, et al (2019). Platelet-rich Plasma Injection in Osteoarthritis of the 
Knee? Journal on Recent Advances in Pain, 5(1): 1-15
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