Medica Stem Cell fro Knee Arthritis
                     Stem Cell Therapy for
 Knee Arthritis 
• Overview
• What is knee Arthritis?
• Symptoms of Knee Arthritis
• Causes of Knee Arthritis
• Conventional Treatment for Knee Arthritis
• Regenerative Treatment for Knee Arthritis
Overview
Arthritis pain and swelling in your knees? 
Are you looking for alternate treatments 
like steroid injections or surgery? Here 
comes our non-surgical regenerative cell 
therapy to help repair the irreparable knee 
and regain mobility.
 What is knee Arthritis?
Knee arthritis is one of the most common causes of knee pain and 
inflammation. There are varied forms of knee arthritis. The most common 
is osteoarthritis, followed by rheumatoid arthritis.
Osteoarthritis, otherwise termed as wear-and-tear arthritis, is a 
degenerative condition where the cartilage gradually wears away. Cartilage 
provides a natural protective cushioning effect between the joints. Wear 
and tear of cartilage cause the joint bones rub against each other and get 
exposed, leading to pain and inflammation.
Rheumatoid arthritis is an autoimmune disorder where the immune 
system attacks itself. It affects the knees by damaging the cartilage and 
softening the bone.
Knee Anatomy 
Symptoms of Knee Arthritis
You may experience the following symptoms in the early stages of knee arthritis, 
including:
Pain especially while straightening or bending the knees or during weightlifting
Tenderness
Swelling due to fluid accumulation in the joint
 
Stiffness due to prolonged sitting or when you get up from the bed 
Limited range of motion
Warmth sensation 
Symptoms of Knee Arthritis
Cracking noise while climbing the steps
Patients usually report a long duration of mild symptoms that may become 
severe with sudden changes.
At the later stage, the knee muscles around the affected portion weaken, 
and you may see changes in knee shape. This condition is termed as joint 
deformity where the knees may later point inwards or outwards. 
Additionally, there will be constant pain with or without activity.
Causes of Knee Arthritis
    Females are more prone to be affected by knee arthritis, compared to males. Knee 
arthritis affects people in varied ways, where the symptoms may differ from one 
another. The common factors that cause knee arthritis include:
 • Ageing – Knee arthritis affects elders comparatively. However, it can affect even 
younger individuals.
 • Obesity – Overweight condition puts heavy pressure on the knees. Hence as time goes 
on, cartilage will break down due to extra weight creating pressure in the knee joint.
• Hereditary factors – People at a young age are getting affected with knee arthritis due 
to the defect in the gene responsible for collagen production. Collagen fibre along 
withelastin,  proteoglycans and glucosaminoglycan forms cartilage matrix, which 
cushions the joint.
Causes of Knee Arthritis
Family history
  Knee injury due to its overuse– Especially athletes and labourers who 
frequently damage their joints, bones, tendons, and ligaments due to 
overuse of knees are more prone to knee arthritis.
Trauma
Other metabolic disorders – Iron overload as well as excess secretion of 
growth hormone increases the risk to develop knee arthritis.
  Vitamin D and Calcium deficiency
Conventional Treatment for Knee Arthritis
   Treatment for knee arthritis includes both surgical and non-surgical procedures which aim to improve 
the strength and function of joints by controlling the symptoms and avoid further joint damage.
Initial treatment includes:
   • R.I.C.E. Formula (Rest, Ice therapy, Compression, and Elevation) as a home treatment to limit the 
activities that may aggravate the symptoms.
   • Medications such as analgesics aim to reduce the pain, and non-steroidal anti-inflammatory drugs 
(NSAIDs) helps in reducing pain and inflammation. But its consumption for a long time  leads to 
potential side effects including heart, gastrointestinal, and kidney problems.
Hyaluronic acid is a type of lubricating fluid present in the knee joint. Hence, the physician may 
recommend hyaluronic acid injection for better joint flexibility. Administration of corticosteroid  
injections into the knee provides short-term relief for only 1-3 weeks by reducing inflammation, but 
they have systemic and local adverse side effects.
Conventional Treatment for Knee Arthritis
Activity modification such as reducing activities like knee bending 
and climbing stairs may help in slowing down the arthritis 
development. Lifestyle changes that aim at reducing the overall    
weight may prevent the condition from getting worse. Physicians 
may recommend physical therapy, muscle strengthening exercises, 
or using assistive devices like canes, once you are  relieved from 
knee pain.
 Surgical methods include joint distraction, knee arthroscopy, knee 
osteotomy, and partial or total joint replacement. Your physician 
may recommend these options if non-surgical methods do       not 
yield any improvement. But joint replacement surgery is only 
considered as the last resort since it involves an extensive 
rehabilitation period after the surgery and there may be a   
repetitive chance of joint replacement in the future.
Regenerative Treatment for Knee Arthritis
Here comes regenerative cell treatment which can be a potential alternative 
to surgery. Platelet-Rich Plasma (P.R.P.) therapy for knee arthritis provides a 
one-stop solution to your long-lasting symptoms by restoring normal 
structure and function. You can see significant improvement in 2-4 weeks 
after undergoing P.R.P. therapy.
A research study published in the journal Arthroscopy revealed that P.R.P. 
injections were significantly more effective than hyaluronic acid injections by 
providing long term pain relief with improved joint function. Hyaluronic acid 
can only lubricate the knee joint, but it cannot treat cartilage loss, unlike 
P.R.P. therapy [1].
Another scientific study revealed that regenerative cell therapy might provide 
better pain relief compared to NSAIDs drugs and corticosteroid injections [2].
Regenerative Treatment for Knee Arthritis
Compared to corticosteroid injections, P.R.P. therapy provides more 
long-term relief from joint pain and enhances the quality of life in a 
shorter duration. People think that P.R.P. treatment is just like 
cortisone. But it is not the fact. Long-term use of cortisone 
injections will ultimately suppress the body’s natural healing 
mechanism and end up with knee replacement surgery. But P.R.P. 
therapy aims at repairing the injured tissue by stimulating your 
body’s healing mechanism naturally. Hence, you do not end up with 
surgery in the later stage [3].
Recently, SVF (Stromal Vascular Fraction) cell therapy in elders with 
grade 2-4 degenerative knee osteoarthritis is considered to be 
safe, rapid, and effective with significant improvement in their 
quality of life [4]. Nevertheless, the use of BMAC (Bone Marrow 
Aspirate Concentrate) therapyis equally safe and beneficial [5].
So, no more delays! Do not let yourself 
feel down with knee arthritis problem. 
You can use your body’s natural repair 
mechanisms to heal irreparable tissues 
if you opt for regenerative cell 
treatment.
Want to more 
about 
Regenerative 
Treatment Visit 
our website for 
more information: 
medicastemcells.c
om