Long-term alcohol misuse can lead to wet brain syndrome, often known by its medical name, Wernicke-Korsakoff syndrome, a neurological disorder that is catastrophic and frequently permanent. Wernicke's encephalopathy and Korsakoff's psychosis are two separate but connected disorders that fall into this category. Long-term alcohol misuse can lead to wet brain syndrome, often known by its medical name, Wernicke-Korsakoff syndrome, a neurological disorder that is catastrophic and frequently permanent. Wernicke's encephalopathy and Korsakoff's psychosis are two separate but connected disorders that fall into this category.