Is in vitro fertilization (IVF) associated with perinatal affective disorders?
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Dr. Shilpa Bhandari (M.P.)-453111
MD Gynaecology
DM Reproductive Medicine and Surgery
Is in vitro fertilization (IVF) associated with perinatal 
affective disorders?
 Highlights
• IVF is not associated with affective symptoms during pregnancy and the postpartum.
• Women who resorted to IVF could have less perinatal depressive symptoms.
• More controlled studies are needed to draw definitive conclusions about this topic.
Abstract
Background
Since mothers who undergo in vitro fertilization (IVF) may experience more anxiety and 
depressive symptoms than mothers who conceive naturally, a review of the literature was 
conducted to investigate whether IVF may be considered a risk factor for the development 
of anxiety or depression during pregnancy and post-partum.
Methods
A thorough search of 
articles in Pubmed, 
PsycINFO and Isi 
Web of Knowledge 
was performed in 
order to produce a 
comprehensive 
review regarding the 
potential association 
of in vitro 
fertilization and 
anxiety/depression.
Results
The search resulted in a total of 
10 articles. Contradictory results 
were reported in the articles 
about the possible association 
between IVF and the occurrence 
of anxiety and depressive 
symptoms both during 
pregnancy and postpartum 
period. Three studies found that 
women who resorted to IVF 
showed less anxiety and 
depressive symptoms than 
those who conceived naturally 
especially with the progression 
of pregnancy and in the 
postpartum.
Limitations
Vulnerability to affective disorders of women affected by infertility may be independent 
from the outcome of IVF. Other limits are the limited research in this area, the small 
sample sizes, the heterogeneity of the tools used to assess affective symptoms.
Conclusions
The available data indicate that IVF is not associated with perinatal affective symptoms. 
Women who resorted to IVF could have less perinatal depressive symptoms as the result of 
a positive outcome of the technique and the satisfaction of the desire to become mothers. 
Further studies are necessary in order to draw definitive conclusions about this topic.
Source - https://www.sciencedirect.com/science/article/abs/pii/S0165032720326021
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