Cell strainers emerge as indispensable tools in the sample preparation toolkit, ensuring the quality and reliability of cellular samples for downstream applications. This comprehensive guide equips researchers with a profound understanding of cell strainers' functions, types, and best practices, enabling them to harness the full potential of these tools in achieving reproducible and accurate results in antibody cell separation. The role of cell strainers is pivotal in advancing scientific discovery and innovation in the fields of biology and medicine.