Dura Substitute Market Report Analysis With Industry Share Published by Leading Research Firm
                     Dura Substitute Market: Introduction
According to the report, the global dura substitute market was valued at US$ 175.6 Mn in
2020 and is projected to expand at a CAGR of 5.9% from 2021 to 2031. Dural substitute is a
medical device used in surgeries to repair dura mater, the outermost layer that covers and
protects the brain. Animal collagen or nanofibers woven together with an elastic material to
form a soft tamponade can also be used to create a dural substitute.
Dural substitutes are required to prevent CSF leaks and to allow dural openings to heal after
surgery. Dural substitutes can be biological or synthetic, harvested from animals or human
cadavers,  and used as an onlay or  suturable grafts.  The key advantage of  using a dural
substitute is that it is similar to the patient's dura and can absorb and integrate into the host
tissue.
Increase in need of neurosurgery due to rise in the number of road accidents and sports
injuries is a major factor boosting the growth of the global market. However, product recalls
is anticipated to hamper the growth of the market.
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Increase  in  Popularity  of  Biomimetic-synthetic-absorbable  Dural  Graft  among  Medical
Professionals
Dural  repair materials are transitioning from animal tissue-derived materials to synthetic
materials, as well as from inert to absorbable properties. Biomimetic patch is a new dural
repair  product  that  provides  functional  properties  similar  to  alternate  therapies.  The
biomimetic  patch  has  another  three-dimensional  nonwoven  microfiber  structure  that  is
both mechanically strong and biocompatible. The biomimetic structure and proper rate of
degradation of the new absorbable dura replacement can lead to significant regeneration of
the  dura  mater,  thereby  providing  a  novel  method  to  dural  defect  repair.  Redura
manufactured  by  Medprin  is  an  example  of  biomimetic  patch  that  is  FDA-approved
degradable material made up of poly-L-lactic acid (PLA).
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Biological Grafts Segment to Lead Dura Substitute Market
In terms of material, the global dura substitute market has been bifurcated biological graft
and synthetic graft. The biological graft segment has been split into autografts, allografts,
and xenografts.  The synthetic segment has been segregated into polytetrafluoroethylene
and  others.  Biological  grafts  are  manufactured  by  bioengineering  tissues  from  various
animals such as cows (bovine pericardium) and pigs (porcine intestinal sub mucosal layer).
These materials are rich in collagen fibers and have a low tendency to induce immunological
responses.  Favorable  mechanical  properties  for  suturability  and  desirable  resorption
properties for  tissue remodelling are often mutually incompatible  in biologically  derived
dura replacements. Many biologic grafts have the benefit of being fully reformed, in which
the  graft's  natural  components  (e.g.,  collagen)  recruit  cell  infiltration  and  angiogenesis,
which engage in the graft material's restructuring.
Autografts, allograft, or xenografts, and commercially processed graft material derived from
bovine  collagen sources  or  human cadaveric  tissues  are  options  for  the repair  of  dural
defects.
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Neurosurgery to Dominate Global Dura Substitute Market
Based  on  application,  the  global  dura  substitute  market  has  been  classified  into
neurosurgery and spinal surgery. The neurosurgery segment held major share of the market
in 2020. Dural  repair  after craniotomy is a popular  treatment outcome in neurosurgery.
Dural closure is particularly important after surgeries in the posterior fossa or skull base,
where the risk of CSF leak is significant. This augments the demand for dura substitutes in
neurosurgical procedures. Dural substitutes are used for different neurosurgeries such as
cranial  reconstruction,  tumor  removal  -  all  craniotomies,  skull  base,  neurovascular
procedures, posterior fossa decompressions, etc. The dura substitute are routinely used in
neurosurgical  procedures  hence  by  application  neurosurgery  segment  is  held  major
segment of market during forecast period.
Hospitals to be Major End-user
In terms of end-user,  the global  dura substitute market has been divided into hospitals,
ambulatory surgical centers, and others. The hospitals segment held major market share in
2020. The growth of the segment can be ascribed to increase in hospitalization of patients
for spine and cranial surgeries and rise in the use of dura substitutes for dural repair. The
most  common  types  of  neurosurgery  procedures  performed  in  hospitals  include
craniotomy, chiari decompression, and spinal fusion. Rise in the rate of hospitalization for
duraplasty procedures is anticipated to drive the segment during the forecast period
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North America to Lead Global Dura Substitute Market
In  terms  of  region,  the  global  dura  substitute  market  has  been  segmented  into  North
America,  Europe,  Latin  America,  Asia  Pacific,  and  Middle  East  &  Africa.  North  America
dominated  the  global  dura  substitute  market  in  2020,  accounting  for  41.8%  share.
Developed healthcare infrastructure and presence of patient specific healthcare systems are
factors fueling the growth of the dura substitute market in North America.
The U.S. dominated the market in North America due to rapid adoption of new technologies
for soft tissue repair, presence of key players, and higher penetration of research activities
across the country. Moreover, rise in burden of neurosurgical diseases is leading to increase
in  cranial  and spinal  duraplasty,  which,  in  turn,  is  likely  to  boost  the demand for  dura
substitute in North America.
Competition Landscape
The global dura substitute market is fragmented due to presence of large number of leading
players.  Key players  operating in  the global  market  include Cook Medical  LLC,  B.  Braun
Melsungen AG, Integra LifeSciences, Cousin Surgery, W. L. Gore & Associates, Inc., Biosynth
Lifesciences,  Acera  Surgical,  Inc.,  Medprin,  Medtronic,  Stryker,  DePuy  Synthes,  Gunze
Limited, Baxter, Bennett Health, Inc., RTI Surgical, and Natus Medical Incorporated.
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