Human Microbiome Market to Witness Widespread Expansion by 2028
                     Human Microbiome Market: Introduction
According to the report,  the global human microbiome market was valued at US$ 1.3 Bn in
2020 and is projected to expand at a CAGR of 7.1% from 2021 to 2028. Microbiome is the
genetic component of the entire range of microorganisms, including bacteria, fungi, protozoa,
and viruses, which live inside and on the human body. The beneficial bacteria present in the
microbiome assist  the digestion of  food,  regulation of  the immune system,  and protection
against other disease-causing bacteria.
This  ability  is  being  harnessed  by  start-ups  and  companies  in  the  microbiome-based
therapeutics market to create drugs aimed at treating conditions, which have been shown to
have  a  link  with  imbalance  in  the  microbiome.  The  human  microbiome  market  has  been
analyzed by studying it as two individual markets, the microbiome-based diagnostics market
and the microbiome-based therapeutics market.
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Mergers & Acquisition and Innovation among Key Players to Drive Global Market
In August 2020, Seres Therapeutics announced the success of its flagship product SER-109 in
the phase 3 trail.  SER-109 treatment is likely to reduce the risk of gastrointestinal infection
caused by Clostridium difficile. In May 2020, Rebiotix and Ferring Pharmaceuticals announced
positive result from the preliminary phase 3 data from fecal microbial transplantation product
RBX2660.
In June 2020, Debiopharm and Takeda Pharmaceutical Company entered into partnership to
develop the microbiome therapeutics for the treatment of the IBD and other gastrointestinal
diseases. In April 2020, Second Genome and Gilead Sciences, Inc. entered into partnership to
identify  the  biomarkers  for  Gilead  clinical  candidates  & drug  targets  for  IBD.  Moreover, in
February 2020, Enterome partnered with the BIOASTAR Institute to explore the microbiome
derived  cancer  immunotherapies. In  November  2019,  Finch  extended  its  partnerships  with
Takeda for developing microbiome-based therapeutics by utilizing Finch human first discovery
platform
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Increase  in  Research  &  Development  Activities  in  Metagenomics  and  Next-generation
Sequencing Render Microbiome-based Testing Easier and Cheaper
Advances  in  metagenomics  and  next-generation  sequencing  have  made  microbiome-based
testing easier and cheaper, paving the way to carry out rapid analysis of the genomic content of
microorganisms  from  human  sample.  This  has  strengthened  the  development  process  for
microbiome-based diagnostics.
Gastrointestinal  and  metabolic  disorders  are  likely  to  capture  the  leading  share  of  the
diagnostics market in 2020, owing to rise in focus of companies toward developing an easy
analysis platform for gut health-based disorders, such as irritable bowel syndrome and Crohn’s
disease.
For  instance,  Metabiomics  is  developing  molecular  diagnostics  for  detecting  markers  of
colorectal cancer. Existing tests for colorectal cancer rely on invasive colonoscopies. Hence, the
non-invasive test developed by Metabiomics (which uses a stool sample to evaluate patient’s
gut microbiome) will be a unique opportunity for the company to excel in a market having huge
unmet needs.
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Metagenomic Sequencing Segment to Grow at High Rate
In  terms  of  technology,  the  global  human  microbiome  market  has  been  bifurcated  into
metagenomic sequencing and 16s rRNA sequencing. The metagenomic sequencing segment is
likely to expand at a higher CAGR from 2021 to 2028. Growth of the segment can be attributed
to  the  preference  of  start-ups  in  providing  comprehensive  data  profiles  of  the  inherent
microbiome of the individual being tested. Rise in investments by companies and partnerships,
which provide unique opportunity for companies to offer technology-driven products in the
market is anticipated to propel the segment during the forecast period.
GI & Metabolic Disorders Segment to Dominate Human Microbiome Market
Based  on  indication,  the  global  human  microbiome  market  has  been  classified  into
gastrointestinal  &  metabolic  disorders,  women’s  health,  cancer,  and  others.  The
gastrointestinal & metabolic disorders segment dominated the global market in 2020 and the
trend is projected to continue during the forecast period. The segment is driven by focus on
these diseases by leading companies in the market. uBiome, a market leader in the microbiome
diagnostics  market,  recently launched SmartGut for  microorganisms associated with several
common gut symptoms such as Crohn’s disease and ulcerative colitis.
The  growth  of  the  segment  can  be  attributed  to  high  number  of  microbiome  diagnostic
companies and ease of non-invasive testing provided by this method.
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North America to Dominate Global Market
In  terms of  region,  the  global  human microbiome market  has  been segmented into  North
America,  Europe,  Asia  Pacific,  Latin  America,  and  Middle  East  &  Africa.  North  America
dominated the global human microbiome market in 2020, followed by Europe. North America is
likely to dominate the human microbiome market, attributed to rise in investments in research
&  development,  ongoing  clinical  trials  for  conducting  microbiome  projects,  stringent
governmental  regulations,  and  technological  advancements.  Large  number  of  programs  in
clinical stage in North America and increase in awareness about the concept of microbiome-
based therapies are few driving factors for the regional growth of the market.
Europe is likely to account for the second-largest share of the global human microbiome market
during the forecast period, owing to prominent contribution of companies in the microbiome
research and diagnostics. Most of the therapies in the pipeline is anticipated to be first released
in the region.  This  is  likely  to  propel  the human microbiome market  in  Europe during the
forecast period.
Competition Landscape
The  global  human  microbiome  market  is  consolidated  in  terms  of  number  of  players.  Key
players in the global market include AOBiome, Enterome Biosciences SA, Metabiomics Corp.
(BioSpherex  LLC),  Microbiome  Therapeutics  LLC,  Osel,  Inc.,  Second  Genome,  Seres
Therapeutics,  Synthetic  Biologics,  Inc.,  Vedanta  Biosciences,  4D  Pharma,  and  Ferring
Pharmaceuticals
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