Impact of Outbreak of COVID-19 on Oligonucleotide Synthesis Market
                     Transparency  Market  Research  (TMR)  has  published  a  new  report  titled,  ‘Oligonucleotide
Synthesis Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2019–
2027’. According to the report, the global a market was valued at US$ 1,966.2 Mn in 2018 and
is projected to expand at a CAGR of 9.5% from 2019 to 2027.
Overview
 An oligonucleotide is a single-stranded chain composed of a number of nucleoside units
connected together by the process of phosphodiesterase, which typically synthesizes small
fragments on nucleic acid sequences up to 25 bases, with the desired structure and a given
sequence needed for  different  applications.An oligonucleotide is  a  single-stranded chain
composed  of  a  number  of  nucleoside  units  connected  together  by  the  process  of
phosphodiesterase, which typically synthesizes small fragments on nucleic acid sequences
up  to  25  bases,  with  the  desired  structure  and  a  given  sequence  needed  for  different
applications.
 There are various lengths of oligonucleotides, and sequences and design modifications
available. Thanks to the increasingly developing biotechnology and life sciences markets,
there has been a n ever-rising need for oligonucleotides on the global market, as well as
rising acceptance and use of oligonucleotides in clinical and diagnostic fields.
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Technological Advancements in Synthetic Chemistry to Drive Market
 The advances in the technological development of organic molecules are expected to
drive the growth of the oligonucleotide synthesis market
 The advanced synthesis of oligonucleotides provides longer oligos with better sequence
fidelity and higher purity that can be used in a number of molecular biology applications
 Various  pharmaceutical  and  biotechnology  companies  are  continuously working  on
developing newer and advanced methods in synthetic chemistry
 For instance, Integrated DNA Technologies, leader of synthesized oligonucleotides has
developed various pioneered methods to synthesize oligonucleotides of extreme lengths.
The company has developed oligonucleotides up to 200 base length which is used with mass
spectrometry for the manufacture of mini-genes.
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Synthesized oligonucleotides Segment to Dominate Market
 Based on product type, the global oligonucleotide synthesis market has been divided
into  reagents  &  consumables,  equipment,  and  synthesized  oligonucleotides.  The
synthesized oligonucleotides segment has been bifurcated into DNA oligonucleotides, RNA
oligonucleotides, and others.
 The  synthesized  oligonucleotides  segment  dominated  the  global  oligonucleotide
synthesis market in 2018 and the trend is projected to continue during the forecast period.
Synthesized oligonucleotides are widely  used in research as  well  as  in  therapeutics  and
diagnostics  applications.  Synthesized  oligonucleotides  are  ready  to  use  oligonucleotides.
These are also available as customized oligos prepared as per need. There are two types of
commercially  used  synthesized  oligonucleotide:  DNA  oligonucleotides  and  RNA
oligonucleotides. Bridged Nucleic Acid (BNA) and Locked Nucleic acid (LNA) are the other
types of synthesized oligonucleotides used in research.
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Research Applications to be Highly Lucrative Segment
 In terms of application, the global oligonucleotide synthesis market has been classified
into research, diagnostic and therapeutic. Among the applications, the research applications
segment dominated the global oligonucleotide synthesis market in 2018. Rising R&D focus
of pharmaceutical  & biotechnology companies, along with technological  advances in the
techniques such as polymerase chain reaction, and next generation sequencing, are some of
the  major  factors  driving  the  growth of  the  research  segment  in 2018. However,  rising
applications in therapeutics,  and growing R&D in RNAi  therapeutic drugs is  expected to
drive the growth of the therapeutic segment during 2019-2027
North America to Dominate Global Market
 In terms of region, the global oligonucleotide synthesis market has been segmented into
North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America
dominated the global Oligonucleotide Synthesis market in 2018, followed by Europe.
 North America accounted for major share of the global oligonucleotide synthesis market
in 2018,  According  to  the  data  obtained  from  the  ongoing  clinical  trials  in  the
oligonucleotides segment,  there were more than 70 oligonucleotide ongoing or recently
completed trials in the U.S. alone. Fast growing life science industry, rising focus on genetics
and genomics in the research and diagnostics applications in North America, and growing
focus of pharmaceutical organizations on oligonucleotides as therapeutic agents comprising
RNAi and antisense therapeutics are driving demand for oligonucleotides in North America.
 However,  rising  focus  on  personalized medicine and growing biotechnology  and life
science research activities in Asia Pacific, along with rising healthcare spending on research
& development in India, China, and Japan are factors expected to boost the growth of the
market for oligonucleotide synthesis in Asia Pacific from 2019 to 2027.
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Competitive Landscape
 The  global  oligonucleotide  synthesis  market  is  fragmented  in  terms  of  number  of
players. Key players in the global market include GE Healthcare, Thermo Fischer Scientific,
Agilent  Technologies,  Inc.,  Merck  KGaA,  Integrated  DNA  Technologies,  Inc.,  Kaneka
Eurogentec  S.A.,  BioAutomation,  Gene  Design,  Inc.,  Eurofins  Genomics, and ATDBio,
Ltd. among others.
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