Can New-born Stem Cells Be Used to Treat Hepatitis
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Can New-born Stem Cells Be Used to 
Treat Hepatitis?
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The liver which is located in the upper right-hand side 
of the abdomen, performs many important functions 
that might affect the regular metabolism of human 
body – like:
• Breaking down carbohydrates, fats and proteins, 
storing glycogen, minerals and vitamins,
• Filtering toxins and
• Eliminating cholesterol, hormones and bilirubin.
But, sometimes, the liver might dysfunction or might suffer from an inflammation 
as a reaction that occurs when the liver cells are attacked by disease-causing 
microbes or substances.
What Is Hepatitis?
Hepatitis is also one such infection. It is caused by other viruses, bacteria, 
parasites, and toxin reactions to drugs, alcohol, and chemicals leading to liver 
inflammation, failure and cirrhosis.
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What Are The symptoms Of Hepatitis?
According to Centers for Disease Control 
and Prevention (CDC), approximately 
4.4 million people across the world are 
affected by chronic hepatitis B and C, in 
which the symptoms start developing 
In some cases ofs lhoewplay.t itis, symptoms may not occur at 
all, until there is a liver damage. In acute hepatitis 
however, flu-like symptoms, fatigue, dark urine, stomach 
ache, weight loss and skin and eyes turning yellow are 
some of the common symptoms.
So, the treatment also depends upon its types and 
severity.
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How Is Hepatitis Treated?
While Hepatitis A is an acute and short-term 
disease, Hepatitis B and C are more likely to 
become chronic.
In case of hepatitis A, (which is caused by 
consuming contaminated food or water), the 
treatment is largely based on addressing the 
symptoms, monitoring the liver health and getting 
vaccinated to prevent the affected from falling 
sick. Medication, hospitalisation or transplantation 
Hepatitis B and C, which is tranissm raitrte dre tqhuroiruegmhe nintj einc thioenp autsitei,s .and sexual contact, 
is normally treated with antiviral medications. Although an expensive treatment 
procedure, but it requires regular medical evaluation, monitoring, and testing, to 
check whether the virus is responding to the treatment. However, as a result of 
chronic hepatitis C, if someone develops liver cirrhosis, the patient might have to 
get a liver transplantation done. 
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Can New-born Stem Cells Be Used to Treat Hepatitis?
 Haematopoietic Stem Cells was used to treat Hepatitis C
A study had shown that, in November 2000, a 45-year-old man was diagnosed 
with hepatitis C. Going deep, except getting a few tattoos done, no proper 
source of the viral infection was found.
To reduce the viral load, he may have been given a combination of antiviral 
therapy, but he developed a progressive pancytopenia, even after the 
discontinuation of the antiviral therapy. He also became transfusion dependent. 
With the outcome of the treatment, it was decided that the patient might 
eventually need umbilical cord blood (haematopoietic) stem cell transplantation. 
So, since he did not have any siblings, baby stem cells from unrelated umbilical 
cord blood were offered for transplantation. Due to Haematopoietic Stem cells’ 
ability to rebuild blood, except a small post transplantation complication, 9 
months after, his liver function was tested normal and the chances of the 
returning of the viral load were below the levels of detection.
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 Peripheral infusion of UCMSCs showed good therapeutic 
effects for HBV-related liver failure
In a study, which had 64 patients affected with HBV-related liver failure and 59 
patients with HBV-related liver cirrhosis, after prolonged umbilical cord 
mesenchymal stem cell (MSC) treatment, significant changes were observed. In 
fact, those who belonged to the age in-between 16 and 60 years, after the 
therapy, the patients were excluded from:
1. Severe complications including gastric vein rupture, haemorrhage and 
septicaemia
2. Other autoimmune treatable diseases
3. Liver transplantation
4. Alcoholic liver disease
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Overall, the long-term effectiveness of umbilical cord (cord blood) stem cell 
therapy could further be judged in large-scale and well-controlled trial. 
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Source: https://www.cordlifeindia.com/blog/can-new-born-stem-cells-be-used-to-treat-hepatitis/
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