HRIG Vaccine is indicated for immediate passive immunization after severe rabies exposure in previously unvaccinated individuals. HRIG Vaccine contains purified Human Rabies Immunoglobulin that provides ready-made antibodies to neutralize the rabies virus at the wound site before the Anti Rabies Vaccine stimulates active immunity. The recommended dose of HRIG Vaccine is 20 IU/kg body weight, infiltrated into and around the wound, with any remaining volume administered intramuscularly at a site distant from the vaccine injection. Most reactions to HRIG Vaccine are mild, such as injection-site pain or low-grade fever, while hypersensitivity is rare. Proper cold-chain storage (2–8°C) and compliant Wholesale Pharmacy sourcing are essential to maintain product potency and patient safety.