Best Functional medicine Doctor in Glenview
                     The Link between Gut Health, 
Fasting, and Autoimmune 
Diseases
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The Link between Gut Health, Fasting, 
and Autoimmune Diseases
Prevalence and Types of Autoimmune Diseases
 Autoimmune disease affects hundreds of millions of people worldwide, and its 
prevalence is increasing.
 
 There are 100+ known autoimmune disease types. 
 Some of the more prevalent include type 1 diabetes, rheumatoid arthritis (RA), 
systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD)
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Chronic Inflammation and Triggers
 For a patient with a history of chronic systemic 
inflammation and an antecedent, like an 
inflammatory diet or a psychological stressor 
could act as a trigger to precipitate autoimmune 
disease or disease flare-up.
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The Link between Intestinal Permeability and 
Autoimmune Diseases
 Genetic and environmental factors have long been understood to 
trigger autoimmune disease. 
 In 2000, a third element—intestinal permeability commonly known 
as leaky gut which allows passage of antigens—macromolecules, 
toxins, food proteins, or others—from the gut into the body: 
intestinal permeability was found, Zonulinis the master regulator 
of intestinal permeability that opens the door to several chronic 
inflammatory conditions. 
 Zonulin is found in abundance in rheumatoid arthritis, systemic 
lupus erythematosus, irritable bowel syndrome, and other 
autoimmune diseases Using zonulin as a biomarker for leaky gut is 
linked to age-related inflammation and frailty (decreased muscle 
strength). 
 Pathogenic bacteria and gliadin are major triggers that cause the 
release of zonulin. Lactobacillus rhamnosus GG inhibits gliadin 
from altering intestinal permeability. 
 This research contributes to a growing body of evidence showing 
the efficacy of healthy bacteria in treating the chronic 
inflammation implicated in autoimmune diseases.
                                                                                                      
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Gut Microbiome and Chronic Diseases
Dysbiosis of gut microbiota has been closely linked to several 
diseases, such as obesity, type 2 diabetes, hypertension, 
necrotizing enterocolitis, and inflammatory bowel diseases.
  Healthy lifestyle factors, including a diversified diet, limited 
consumption of processed and refined foods, and consumption of 
adequate dietary fiber, may all promote a healthy microbiome. 
Foods and nutrients that potentially boost immune function also 
tend to promote gut health. 
For example, consuming a diverse array of fruits and vegetables 
rich in antioxidants, anti-inflammatory nutrients, and 
phytochemicals may reduce oxidative stress, support the liver to 
promote efficient biotransformation and detoxification, and boost 
overall immune system function.
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Strategies for Managing Autoimmunity
Fasting is the fastest way to bring autoimmunity under control. After 72 hours of water-only 
fasting, autophagy and apoptosis changed in a favorable direction. 
In addition, components of the innate immune system were boosted compared to baseline 
measurements. 
Timed eating is another way to benefit the immune system. Timed eating is where you 
consume three meals per day within an eight-hour time frame at 1 pm, 4 pm, and 8 pm. 
After 12 months of TRE, inflammatory markers (interleukin 6, interleukin 1-beta, and TNF-
alpha) were reduced, and both insulin sensitivity and lipid profiles were significantly 
improved compared to controls.
Intermittent fasting enhances beneficial gut bacteria and increases short-chain fatty acids 
that promote healthy immune function. Please consult with your physician before engaging 
in any kind of fasting routine as the extent of fasting and support during fasting should be 
personalized for optimum outcome.
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                                     Thank You
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