AFINITOR 10MG | EVEROLIMUS | MHP
                     AFINITOR 10MG | EVEROLIMUS | 
MHP
Million Health Pharmaceuticals
DESCRIPTION:
 Afinitor 10mg is a derivative of Rapamycin 
(sirolimus) and works similarly to Rapamycin 
as an mTOR (mammalian target of 
rapamycin) inhibitor.
 It is normally used as an immunosuppressant 
to prevent rejection of organ transplants. 
In a similar fashion to other mTOR inhibitors 
Everolimus' effect is solely on the mTORC1 
protein and not on the mTORC2 protein.
STAGES OF STOMACH CANCER 
PRESCRIBING INFORMATION:
 Afinitor 10mg tablet are mainly indicated for the 
treatment of Renal carcinoma.
 Afinitor 10mg tablets are mainly indicated for the 
treatment of Breast carcinoma.
 Afinitor 10mg tablet are mainly indicated for the 
treatment of Brain carcinoma.
 Afinitor 10mg is also used in various advanced 
stage cancer in stomach, intestines or pancreas.
MECHANISM OF ACTION:
 Everolimus is an mTOR prohibitor, joints at high 
compatibility to FK506 binding protein 12, via 
producing drug complex whichinhibits the 
specific of mTOR.
 This inhibitiondecreases the activity of effectors 
downstream, that may cause blockage of cell 
progression from G1 into S phase, subsequently 
causes cell growth arrest and apoptosis
AFINITOR 10MG
PRODUCT DETAILS:
 Brand : Afinitor 
Ingredients : Everolimus 
Strength : 10mg
Manufactured : Novartis 
Package : 10 tablets 
PHARMACOKINETICS
 ABSORPTION
 The high plasma concentration time of Everolimus is 1 to 2 hours.
The effect of food with Afinitor 10mg that with heavy meal: Reduction of 
systemic exposure to Afinitor 10mg tablet and the high blood plasma 
concentration by 54%.
 DISTRIBUTION
Afinitor 10mg human plasma protein bound with the range of 74%.
  METABOLISM
The metabolism of Everolimus is occurred in liver, which is a substrate of 
CYP3A4.
 EXCRETION
The major route of elimination;
DOSAGE MANAGEMENT
 In breast cancer, renal cell cancer, 
pancreatic cancer, Neuro endocrine 
cancer:
The prescribed dosage is 10mg should 
be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Afinitor 10mg
 is 4.5mg/m2 orally as a single dose.
PRECAUTIONS:
Lymphomas:
 Increased exposure of skin cancers, 
patient may protect from UV light
Serious infections:
 Patients receiving Afinitor 10mg have 
high risk of acquiring various infections 
related to bacteria, virus, and fungi. Anti-
microbial agents are preferred for the 
suspected patients.
Hepatic artery thrombosis:
•  In liver transplant patients, Afinitor
 10mg therapy should not be 
recommended.
Nephrotoxicity:
• Renal function should be monitored 
frequently; caution should be taken while 
usingAfinitor 10mg  in renal impaired 
patients.
Angioedema:
• This may have occurred in the patients 
receiving concomitantly Afinitor
 10mg  tablet with Angiotensin 
converting enzyme agents
SIDE EFFECTS:
• Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
DRUG INTERACTION
• Afinitor 10mg interaction with strong inhibitor of 
CYP3A4, or P-gp, leads to cause decreasing the efflux of 
Everolimus and increase the plasma concentration of 
Everolimus.
• Combination of Afinitor 10mg with verapamil leads to 
increasing the plasma concentration of Everolimus.
• Combination of Afinitor 10mg tablet with Atorvastatin 
or pravastatin causes rhabdomyolysis, due to increasing 
concentration of lipid lowering agents.
• Afinitor 10mg combination with strong CYP3A4 
inducers, causes increasing the exposure of Everolimus.
CONTRAINDICATIONS:
 Some anaphylactic reaction occurs, if 
patients are contraindicated to the 
components present in the Afinitor 
10mg tablets
PREGNANCY:
 Pregnancy category C Afinitor 10mg is 
needed only by the patients after 
knowing the benefits to the mother 
outweighs the risk to fetus.
STORAGE :
 Afinitor 10mg tablet should be kept at 
25°C
Keep the tablet away from moisture, 
heat and light
Dispense only in original container.
MISSED DOSE:
 If patient failed to take a single dose, 
patients must consult with medical 
practitioner and follow the instructions 
given by them.
Or the missed dose should be avoiding 
and follow the regular dosing schedule.
OVERDOSAGE:
 The over dosage of Everolimus is rarely 
occur, in case of over dosage patient 
must be provide with supportive 
measures. The acute toxicity of 
Everolimus over dosage should be 
monitored.
CONTACT US:
 PHONE NO:+91-9940472902
 EMAIL:millionhealthpharmaceuticals@gmai
l.com
 WEBSITEURL:https
://millionpharma.com/afinitor-10-mg.php