EVERMIL 10MG TABLET
                     EVERMIL 10MG TABLET | 
EVEROLIMUS | MHP

Million Health Pharmaceuticals
DESCRIPTION:

 Evermil 10mg is a derivative of Rapamycin 
(sirolimus) and works similarly to Rapamycin 
as an mTOR (mammalian target of rapamycin) 
inhibitor.
It is normally used as an immunosuppressant 
to prevent rejection of organ transplants. 
In a similar fashion to other mTOR inhibitors 
Everolimus' effect is solely on the mTORC1 
protein and not on the mTORC2 protein.
Brain carcinoma

PRESCRIBING 
INFORMATION:

 Evermil 10mg tablet are mainly indicated for 
the treatment of Renal carcinoma.
Evermil 10mg  are mainly indicated for the 
treatment of Breast carcinoma.
Evermil 10mg tablet are mainly indicated for 
the treatment of Brain carcinoma.
Evermil 10mg is also used in various advanced 
stage cancer in stomach, intestines or 
pancreas.
MECHANISM OF 
ACTION:

 Everolimus is an mTOR prohibitor, joints at 
high compatibility to FK506 binding protein 
12, via producing drug complex which inhibits 
the specific of mTOR.
This inhibition decreases the activity of 
effectors downstream, that may cause 
blockage of cell progression from G1 into S 
phase, subsequently causes cell growth arrest 
and apoptosis
PRODUCT 
DETAILS:
Brand : Evermil 
Ingredients : Everolimus 
Strength : 5mg
Manufactured : Glenmark 
pharmaceuticals 
Package : 10 tablets 
PHARMACOKINETIC:

 ABSORPTION:
 The high plasma concentration time of Everolimus is 1 to 2 
hours.The effect of food with Evermil 10mg that with heavy 
meal: Reduction of systemic exposure to Evermil 5mg 10mg, 
and the high blood plasma concentration by 54%.
DISTRIBUTION:
 Evermil 10mg human plasma protein bound with the range 
of 74%.
METABOLISM:
 The metabolism of Everolimus is occurred in liver, which is a 
substrate of CYP3A4.
The metabolites of Everolimus;
DOSAGE 
MANAGEMENT:

 In breast cancer, renal cell cancer, pancreatic cancer, Neuro 
endocrine cancer:
The prescribed dosage is 10mg should be taken as a single 
dose.
In Brain or intracranial cancer:
The prescribed dosage of Evermil 10mg tablet is 4.5mg/m2 
orally as a single dose.
In pediatric:
The usual pediatric dosage of Evermil 10mg in brain or 
intracranial tumor is 4.5mg/m2 should be taken orally as a 
single dose. 
Evermil 10mg tablet should be administered with or without 
food.
PRECAUTIONS:

 Lymphomas:
 Increased exposure of skin cancers, patient may protect from 
UV light
Serious infections:
 Patients receiving Evermil 10mg have high risk of acquiring 
various infections related to bacteria, virus, and fungi. 
Anti-microbial agents are preferred for the suspected patients.
Hepatic artery thrombosis:
 In liver transplant patients, Evermil 10mg therapy should not be 
recommended. 
Nephrotoxicity:
 Renal function should be monitored frequently; caution should 
be taken while usingEvermil 10mg in renal impaired patients. 
SIDE EFFECTS:

 • Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
CONTRAINDICATIONS:

 Some anaphylactic reaction occurs, if patients 
are contraindicated to the components 
present in the Evermil 10mg tablet.
PREGNANCY:

 Pregnancy category C Evermil 10mg is needed 
only by the patients after knowing the benefits 
to the mother outweighs the risk to fetus.
STORAGE :
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 Evermil 10mg tablet should be kept at 25°C
Keep the tablet away from moisture, heat and 
light
Dispense only in original container.
MISSED DOSE:

 If patient failed to take a single dose, patients 
must consult with medical practitioner and 
follow the instructions given by them. Or the 
missed dose should be avoiding and follow the 
regular dosing schedule.

 OVERDOSAGE:
 The over dosage of Everolimus is rarely occur, 
in case of over dosage patient must be 
provide with supportive measures. The acute 
toxicity of Everolimus over dosage should be 
monitored.
CONTACT US:

 PHONE NO:+91-9940472902
 E-MAIL:[email protected]
 WEBSITE URL:https://millionpharma.com/evermil-10-mg.php