EVEROLIMUS EVERTOR 10MG - ANTICANCER DRUGS
                     EVEROLIMUS EVERTOR 10MG 
- ANTICANCER DRUGS | 
BIOCON | MHP
M I L L I O N   H E A LT H   P H A R M AC E U T I C A L S
DESCRIPTION
• Evertor 10mg tablet consist of an active 
ingredient known as Everolimus which is intrude 
with growth of cancer cell and process is slows 
down.Evertor 10mg tablet is not a curable 
medication, which is helps to slow their spreading 
in to the body.
EVERTOR PRESCRIBING INFORMATION
• Primarily Evertor  10mg tablet indicated for the 
treatment kidney carcinoma Breast carcinoma 
Brain carcinoma Everolimus is also indicated in 
various advanced stage cancer in stomach, 
intestines or pancreas.
EVERTOR MECHANISM
• Everolimus is an inhibitor of mTOR, joins at high 
compatibility to FK506 binding protein 12, via 
producing drug complex that inhibits the 
productive of mTOR. This inhibition reduce the 
activity of effectors downstream, which may leads 
to stoppage of cell progression from G1 into S 
phase, Finally causes cell growth arrest and 
apoptosis
 KIDNEY CARCINOMA
ADME PROCESS
• ABSORPTION
The maximium plasma concentration time of Everolimus reaches within 1 to 
2 hours.
• DISTRIBUTION
Albumin human plasma protein bound of 74%.
• METABOLISM
In hepatic Everolimus metabolism is occurred, which is a substrate of 
CYP3A4. The metabolites of Everolimus in 3 process; Three 
monohydroxylated metabolite, Two hydrolytic rings opened products, 
Phosphatidylcholine conjugate of Everolimus.
• ELIMINATION
half life period of Everolimus is 30 hours The elimination primarily via 5% in 
urine; the parent compound has been detected in urine or feces.
PRODUCT 
DETAILS:
Brand : Evertor 
Ingredients : 
Everolimus 
Strength : 10mg 
Manufactured : Biocon 
Package : 10 Tablets in 
a strip 
DOSAGE REGIMEN
• In breast cancer, renal cell cancer, pancreatic 
cancer, Neuro endocrine cancer: The prescribed 
dosage is 10mg should be taken as a single dose. 
In Brain or intracranial cancer: The prescribed 
dosage of Evertoras 10mg a single dose. is 
4.5mg/m2 given orally In pediatric: The pediatric 
dosage of Evertor as a single dose in brain or 
intracranial tumor is 4.5mg/m2 should be given 
orally.
OVER DOSAGE
• The over dosage of Everolimus is limited, If over 
dosage occurs patient must be provide with 
supportive measures. And monitor evidence of 
toxicity in Everolimus over dosage
WHEN TO TAKE THE DRUG EVERTOR
• Evertor 10mg tablets should be given with or 
without food.
EVERTOR CAUSED SIDE EFFECTS
• Hypersensitivity reactions Lymphomas & other 
malignancy Serious infections Kidney graft 
thrombosis Hepatic artery thrombosis 
Nephrotoxicity Hyperlipemia Angioedema 
Interstitial lung disease Thrombocytopenia Male 
infertility Proteinuria New commencement of 
diabetes
SAFETY PRECAUTIONS
• LYMPHOMAS
• Developed hazard of skin cancers, patient may protect 
from UV light
• SERIOUS INFECTIONS
• Patients getting Evertor 10mg have severe risk of achieve 
various infections related to bacteria, virus, and fungi
HEPATIC ARTERY THROMBOSIS
• Evertor 10ng tablet therapy should not be recommended 
in In liver transplant patients,
• EMBRYO FETAL TOXICITY
• using Evertor 10mg in pregnancy condition Causes fetal 
damage
NEPHROTOXICITY
• While using Evertor 10mg tablet in renal 
impaired patients Renal function should be 
monitored frequently; drug use with caution
• INTERSTITIAL LUNG DISEASE
• In Evertor 10mg therapy interstitial lung disease 
occur Blood glucose level should be monitored
DRUG INTERACTION
• Evertor  10mg tablet interaction with strong 
inhibitor of CYP3A4, or P-gp, cause reducing the 
efflux of Everolimus and high plasma 
concentration of Everolimus. Interaction of 
Evertor with strong CYP3A4 inducers, will 
increasing the disclosure of Everolimus. 
Combination ofEvertor with cyclosporine will 
increasing the AUC level of Everolimus 
frequently. 
PREGNANCY & LACTATION
• Pregnancy category of Everolimus C In patients 
Evertor is used only after knowing the benefits to 
the mother exceed the risk to fetus. Breast 
feeding should not be suggested
CONTRAINDICATION
• If patients are contraindicated to the components 
present in the Evertor 10mg tablet. Some 
anaphylactic reaction occurs.
MISSED DOSE
• If the dose is missed, consult with healthcare 
practitioner and follow the instructions given by 
them. Thereby missed dose should be avoid and 
follow the regular dosing schedule.
CONTACT US:
• MOBILE NO:  +91-9940472902
• E-MAIL:  
 [email protected]
• WEBSITE URL:   
https://millionpharma.com/evertor.php