EVEROLIMUS EVERTOR 10MG-converted
                     EVEROLIMUS EVERTOR 10MG - ANTICANCER DRUGS | 
BIOCON | MHP 
 
EVERTOR 
 
DESCRIPTION 
Evertor 10mg tablet consist of an active ingredient known as Everolimus which is intrude with 
growth of cancer cell and process is slows down.Evertor 10mg tablet is not a curable medication, 
which is helps to slow their spreading in to the body. 
EVERTOR PRESCRIBING INFORMATION 
Primarily Evertor  10mg tablet indicated for the treatment kidney carcinoma Breast carcinoma 
Brain carcinoma Everolimus is also indicated in various advanced stage cancer in stomach, 
intestines or pancreas. 
EVERTOR MECHANISM 
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via 
producing drug complex that inhibits the productive of mTOR. This inhibition reduce the activity 
of effectors downstream, which may leads to stoppage of cell progression from G1 into S phase, 
Finally causes cell growth arrest and apoptosis 
ADME PROCESS 
ABSORPTION 
The maximium plasma concentration time of Everolimus reaches within 1 to 2 hours. 
DISTRIBUTION 
Albumin human plasma protein bound of 74%. 
METABOLISM 
In hepatic Everolimus metabolism is occurred, which is a substrate of CYP3A4. The metabolites 
of Everolimus in 3 process; Three monohydroxylated metabolite, Two hydrolytic rings opened 
products, Phosphatidylcholine conjugate of Everolimus. 
ELIMINATION 
half life period of Everolimus is 30 hours The elimination primarily via 5% in urine; the parent 
compound has been detected in urine or feces. 
 
 
 
 
 
EVERTOR 10Mg  
PRODUCT DETAILS: 
Brand : Evertor  
Ingredients : Everolimus  
Strength : 10mg  
Manufactured : Biocon  
Package : 10 Tablets in a strip  
DOSAGE REGIMEN 
In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed 
dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed 
dosage of Evertoras 10mg a single dose. is 4.5mg/m2 given orally In pediatric: The pediatric 
dosage of Evertor as a single dose in brain or intracranial tumor is 4.5mg/m2 should be given 
orally. 
OVER DOSAGE 
The over dosage of Everolimus is limited, If over dosage occurs patient must be provide with 
supportive measures. And monitor evidence of toxicity in Everolimus over dosage 
WHEN TO TAKE THE DRUG EVERTOR 
Evertor 10mg tablets should be given with or without food. 
EVERTOR CAUSED SIDE EFFECTS 
Hypersensitivity reactions Lymphomas & other malignancy Serious infections Kidney graft 
thrombosis Hepatic artery thrombosis Nephrotoxicity Hyperlipemia Angioedema Interstitial lung 
disease Thrombocytopenia Male infertility Proteinuria New commencement of diabetes 
SAFETY PRECAUTIONS 
LYMPHOMAS 
Developed hazard of skin cancers, patient may protect from UV light 
SERIOUS INFECTIONS 
Patients getting Evertor 10mg have severe risk of achieve various infections related to bacteria, 
virus, and fungi 
HEPATIC ARTERY THROMBOSIS 
Evertor 10ng tablet therapy should not be recommended in In liver transplant patients, 
 
EMBRYO FETAL TOXICITY 
using Evertor 10mg in pregnancy condition Causes fetal damage 
ANGIOEDEMA 
While patients receiving concomitantly Evertorwith Angiotensin converting enzyme agents will 
cause angiodema 
NEPHROTOXICITY 
While using Evertor 10mg tablet in renal impaired patients Renal function should be monitored 
frequently; drug use with caution 
INTERSTITIAL LUNG DISEASE 
In Evertor 10mg therapy interstitial lung disease occur Blood glucose level should be monitored 
HEREDITARY DISORDERS 
while using evetor 10mg tablet the conditions occurs like galactose intolerance, glucose-
galactose malabsorption, Evertor 10mg  should not be used may results in diarrhea & 
malabsorption. 
GRAPE JUICE INTERACTION 
avoid these concomitant use with grape juice Causes increasing blood levels of Everolimus 
DRUG INTERACTION 
Evertor  10mg tablet interaction with strong inhibitor of CYP3A4, or P-gp, cause reducing the 
efflux of Everolimus and high plasma concentration of Everolimus. Interaction of Evertor with 
strong CYP3A4 inducers, will increasing the disclosure of Everolimus. Combination ofEvertor 
with cyclosporine will increasing the AUC level of Everolimus frequently.  
 
Combination ketaconazole with Evertor  10mg tablet or other CYP3A4 inhibitors will increase 
the plasma concentration and AUC of Everolimus. Concomitant use of Evertor with verapamil 
leads to increasing the plasma concentration of Everolimus.  
 
Concomitant use of Evertor 10mg with Atorvastatin or pravastatin leads to rhabdomyolysis, due 
to increasing concentration of lipid lowering agents. Evertor interaction with rifampicin will 
decreasing the AUC of Everolimus 
PREGNANCY & LACTATION 
Pregnancy category of Everolimus C In patients Evertor is used only after knowing the benefits 
to the mother exceed the risk to fetus. Breast feeding should not be suggested 
CONTRAINDICATION 
If patients are contraindicated to the components present in the Evertor 10mg tablet. Some 
anaphylactic reaction occurs. 
STORAGE 
Evertor 10mg tablet store at 25°C Store the medicine away from moisture, heat and light 
MISSED DOSE 
If the dose is missed, consult with healthcare practitioner and follow the instructions given by 
them. Thereby missed dose should be avoid and follow the regular dosing schedule. 
CONTACT US: 
MOBILE NO:  +91-9940472902 
E-MAIL:   [email protected] 
WEBSITE URL:   https://millionpharma.com/evertor.php