EVERTOR 5MG TABLETS | EVEROLIMUS | MHP
                     EVERTOR 5MG TABLETS | 
EVEROLIMUS | MHP
Million Health Pharmaceuticals
DESCRIPITION:
 Evertor 5mg is a derivative of Rapamycin 
(sirolimus) and works similarly to 
Rapamycin as an mTOR (mammalian target 
of rapamycin) inhibitor.
It is normally used as an 
immunosuppressant to prevent rejection of 
organ transplants.
In a similar fashion to other mTOR inhibitors 
Everolimus' effect is solely on the mTORC1 
protein and not on the mTORC2 protein.
Brain carcinoma
PRESCRIBING INFORMATION
 Evertor 5mg tablets are mainly indicated for the 
treatment of Renal carcinoma.
 Evertor 5mg tablets are mainly indicated for the 
treatment of Breast carcinoma.
 Evertor 5mg tablets are mainly indicated for the 
treatment of Brain carcinoma.
 Evertor 5mg is also used in various advanced 
stage cancer in stomach, intestines or pancreas 
MECHANISM OF ACTION
 Everolimus is an mTOR prohibitor, joints 
at high compatibility to FK506 binding 
protein 12, via producing drug complex 
whichinhibits the specific of mTOR.
 This inhibition decreases the activity of 
effectors downstream, that may cause 
blockage of cell progression from G1 into 
S phase, subsequently causes cell growth 
arrest and apoptosis
PRODUCT DETAILS
Brand : Evertor
Ingredients : 
Everolimus 
Strength : 5MG
Manufactured : 
Biocon 
Pharma 
Package : 10 
tablets 
PHARMACOKINETICS
 ABSORPTION
The high plasma concentration time of Everolimus is 1 to 2 hours.
The effect of food with Evertor 5mg that with heavy meal: 
Reduction of systemic exposure to Evertor 5mg10mg, and the 
high blood plasma concentration by 54%.
 DISTRIBUTION
Evertor 5mg human plasma protein bound with the range of 
74%.80 ml/kg
 METABOLISM
The metabolism of Everolimus is occurred in liver, which is a 
substrate of CYP3A4.
DOSAGE MANAGEMENT
 In breast cancer, renal cell cancer, 
pancreatic cancer, Neuro endocrine cancer:
The prescribed dosage is 10mg should be 
taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Evertor is 
4.5mg/m2 orally as a single dose.
In pediatric:
The usual pediatric dosage of Evertor in 
brain or intracranial tumor is 4.5mg/m2 
should be taken orally as a single dose.
PRECAUTIONS
 Lymphomas: Increased exposure of skin 
cancers, patient may protect from UV light
Serious infections: Patients receiving 
Evertor 5mg have high risk of acquiring 
various infections related to bacteria, 
virus, and fungi.
Anti-microbial agents are preferred for the 
suspected patients.
Hepatic artery thrombosis: In liver 
transplant patients, Evertor 5mg therapy 
should not be recommended.
SIDE EFFECTS
• Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes.
DRUG INTERACTION
 • Evertor 5mg interaction with strong inhibitor of CYP3A4, or 
P-gp, leads to cause decreasing the efflux of Everolimus and 
increase the plasma concentration of Everolimus
• Combination of Evertor 5mg with verapamil leads to 
increasing the plasma concentration of Everolimus.
• Combination of Evertor 5mg with Atorvastatin or 
pravastatin causes rhabdomyolysis, due to increasing 
concentration of lipid lowering agents.
• Evertor 5mg combination with strong CYP3A4 inducers, 
causes increasing the exposure of Everolimus.
• Concomitant use of Evertor 5mg with cyclosporine causes 
increasing the AUC level of Everolimus frequently.
• Evertor 5mg tablet is interaction with ketoconazole or 
other CYP3A4 inhibitors causes increasing the plasma 
concentration and AUC of Everolimus.
CONTRAINDICATIONS
 Some anaphylactic reaction occurs, if 
patients are contraindicated to the 
components present in the Evertor 5mg
 tablets.
PREGNANCY:
 Pregnancy category C Evertor 5mg is 
needed only by the patients after 
knowing the benefits to the mother 
outweighs the risk to fetus.
STORAGE :
 Evertor 5mg tablet should be kept at 
25°C
 Keep the tablet away from moisture, heat 
and light
Dispense only in original container
MISSED DOSE:
 If patient failed to take a single dose, 
patients must consult with medical 
practitioner and follow the instructions 
given by them.
 Or the missed dose should be avoiding 
and follow the regular dosing schedule.
OVERDOSAGE:
 The over dosage of Everolimus is rarely 
occur, in case of over dosage patient 
must be provide with supportive 
measures. The acute toxicity of 
Everolimus over dosage should be 
monitored.
CONTACT US:
 MOBILE NO: +91-9940472902
 EMAIL:   millionhealthpharmaceuticals@
gmail.com
 WEBSITEURL: 
https://millionpharma.com/evertor-5-
mg.php