RAPACT 5MG TABLETS | EVEROLIMUS | MHP
                     RAPACT 5MG TABLETS | 
EVEROLIMUS | MHP
M I L L I O N   H E A LT H   P H A R M AC E U T I C A L S
DESCRIPTION:
• Rapact 5mg is a derivative of Rapamycin 
(sirolimus) and works similarly to Rapamycin as 
an mTOR (mammalian target of rapamycin) 
inhibitor. It is normally used as an 
immunosuppressant to prevent rejection of organ 
transplants. 
In a similar fashion to other mTOR inhibitors 
Everolimus' effect is solely on the mTORC1 
protein and not on the mTORC2 protein.
RENAL CARCINOMA
PRESCRIBING INFORMATION:
• Rapact 5mg tablet are mainly indicated for the 
treatment of Renal carcinoma.
Rapact 5mg tablet are mainly indicated for the 
treatment of Breast carcinoma.
Rapact 5mg tablet are mainly indicated for the 
treatment of Brain carcinoma.
Rapact 5mg is also used in various advanced 
stage cancer in stomach, intestines or pancreas.
MECHANISM OF ACTION:
• Everolimus is an mTOR prohibitor, joints at high 
compatibility to FK506 binding protein 12, via 
producing drug complex which inhibits the 
specific of mTOR.
This inhibition decreases the activity of effectors 
downstream, that may cause blockage of cell 
progression from G1 into S phase, subsequently 
causes cell growth arrest and apoptosis
RAPACT 5MG
PRODUCT DETAILS:
• Brand : Rapact 
Ingredients : Everolimus 
Strength : 5mg
Manufactured : Natco Pharma Ltd 
Package : 10 tablets 
PHARMACOKINETICS
• ABSORPTION:
• The high plasma concentration time of Everolimus is 1 to 
2 hours.
The effect of food with Rapact 5mg that with heavy meal: 
Reduction of systemic exposure to Rapact 5mg10mg, and 
the high blood plasma concentration by 54%.
DISTRIBUTION:
• Rapact 5mg human plasma protein bound with the range 
of 74%.
METABOLISM:
• The metabolism of Everolimus is occurred in liver, which 
is a substrate of CYP3A4.
EXCRETION:
• The major route of elimination; 
5% in urine; the parent compound has been 
detected in urine or feces. 
The half-life period of Everolimus is relatively 30 
hours
DOSAGE MANAGEMENT:
• In breast cancer, renal cell cancer, pancreatic 
cancer, Neuro endocrine cancer:
The prescribed dosage is 10mg should be taken 
as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Rapact 5mg is 
4.5mg/m2 orally as a single dose.
In pediatric:
The usual pediatric dosage of Rapact in brain or 
intracranial tumor is 4.5mg/m2 should be taken 
orally as a single dose. 
PRECAUTIONS:
• Lymphomas:
• Increased exposure of skin cancers, patient may protect from 
UV light
Serious infections:
• Patients receiving Rapact 5mg have high risk of acquiring 
various infections related to bacteria, virus, and fungi. Anti-
microbial agents are preferred for the suspected patients.
Hepatic artery thrombosis:
• In liver transplant patients, Rapact 5mg therapy should not be 
recommended.
Nephrotoxicity:
• Renal function should be monitored frequently; caution should 
be taken while using Rapact 5mg in renal impaired patients.
SIDE EFFECTS:
• Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
DRUG INTERACTION:
• Rapact 5mg interaction with strong inhibitor of 
CYP3A4, or P-gp, leads to cause decreasing the efflux 
of Everolimus and increase the plasma concentration 
of Everolimus.
• Combination of Rapact 5mg with verapamil leads to 
increasing the plasma concentration of Everolimus.
• Combination of Rapact 5mg with Atorvastatin or 
pravastatin causes rhabdomyolysis, due to increasing 
concentration of lipid lowering agents.
• Rapact 5mg combination with strong CYP3A4 
inducers, causes increasing the exposure of 
Everolimus.
CONTRAINDICATIONS:
• Some anaphylactic reaction occurs, if patients are 
contraindicated to the components present in the 
Rapact 5mg tablet.
PREGNANCY:
• Pregnancy category C Rapact 5mg is needed only 
by the patients after knowing the benefits to the 
mother outweighs the risk to fetus.
STORAGE :
• Rapact 5mg tablet should be kept at 25°C
Keep the tablet away from moisture, heat and 
light
Dispense only in original container.
MISSED DOSE:
• If patient failed to take a single dose, patients 
must consult with medical practitioner and follow 
the instructions given by them. Or the missed 
dose should be avoiding and follow the regular 
dosing schedule.
OVERDOSAGE:
• The over dosage of Everolimus is rarely occur, in 
case of over dosage patient must be provide with 
supportive measures. The acute toxicity of 
Everolimus over dosage should be monitored.
CONTACT DETAILS:
• PHONE NO:+91-9940472902
• E-MAIL:[email protected]
• WEBSITE URL:
https://millionpharma.com/rapact-5-mg.php