ROLIMUS 5MG TABLETS| EVEROLIMUS USES & SIDE EFFECTS
                     ROLIMUS 5MG TABLETS| 
EVEROLIMUS USES & SIDE 
EFFECTS
Million Health Pharmaceuticals
DESCRIPTION
 Rolimus 5mg is a derivative of 
Rapamycin (sirolimus) and works 
similarly to Rapamycin as an mTOR 
(mammalian target of rapamycin) 
inhibitor. 
It is normally used as an 
immunosuppressant to prevent rejection 
of organ transplants. 
Brain carcinoma
PRESCRIBING INFORMATION:
 Rolimus 5mg tablet are mainly indicated 
for the treatment of Renal carcinoma.
Rolimus 5mg tablet are mainly indicated 
for the treatment of Breast carcinoma.
Rolimus 5mg tablet are mainly indicated 
for the treatment of Brain carcinoma.
Rolimus 5mg is also used in various 
advanced stage cancer in stomach, 
intestines or pancreas.
MECHANISM OF ACTION:
 Everolimus is an mTOR prohibitor, joints 
at high compatibility to FK506 binding 
protein 12, via producing drug complex 
which inhibits the specific of mTOR.
This inhibition decreases the activity of 
effectors downstream, that may cause 
blockage of cell progression from G1 into 
S phase, subsequently causes cell growth 
arrest and apoptosis
ROLIMUS 5MG
PRODUCT DETAILS:
Brand : Rolimus 
Ingredients : Everolimus 
Strength : 5mg
Manufactured : Cipla Ltd 
Package : 10 tablets 
PHARMACOKINETICS
 PHARMACOKINETICS
 ABSORPTION:
 The high plasma concentration time of Everolimus is 1 to 2 hours.
The effect of food with Rolimus 5mg that with heavy meal: 
Reduction of systemic exposure to Rolimus 5mg10mg, and the 
high blood plasma concentration by 54%.
DISTRIBUTION:
 Rolimus 5mg human plasma protein bound with the range of 74%.
METABOLISM:
 The metabolism of Everolimus is occurred in liver, which is a 
substrate of CYP3A4.
The metabolites of Everolimus; Three monohydroxylated 
metabolite,
DOSAGE MANAGEMENT :
 In breast cancer, renal cell cancer, pancreatic cancer, Neuro 
endocrine cancer:
 The prescribed dosage is 10mg should be taken as a single 
dose.
In Brain or intracranial cancer:
 The prescribed dosage of Rolimus  5mg is 4.5mg/m2 orally as 
a single dose.
In pediatric:
 The usual pediatric dosage of Rolimus 5mg in brain or 
intracranial tumor is 4.5mg/m2 should be taken orally as a 
single dose. 
PRECAUTIONS:
 Lymphomas:
 Increased exposure of skin cancers, 
patient may protect from UV light
Serious infections:
 Patients receiving Rolimus 5mg have 
high risk of acquiring various infections 
related to bacteria, virus, and fungi. Anti-
microbial agents are preferred for the 
suspected patients.
SIDE EFFECTS:
• Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
DRUG INTERACTION:
• Rolimus 5mg interaction with strong inhibitor of 
CYP3A4, or P-gp, leads to cause decreasing the efflux of 
Everolimus and increase the plasma concentration of 
Everolimus.
• Combination of Rolimus 5mg with verapamil leads to 
increasing the plasma concentration of Everolimus.
• Combination of Rolimus 5mg with Atorvastatin or 
pravastatin causes rhabdomyolysis, due to increasing 
concentration of lipid lowering agents.
• Rolimus 5mg combination with strong CYP3A4 
inducers, causes increasing the exposure of Everolimus.
• Concomitant use of Rolimus 5mg with cyclosporine 
causes increasing the AUC level of Everolimus 
frequently.
CONTRAINDICATIONS:
 Some anaphylactic reaction occurs, if 
patients are contraindicated to the 
components present in the Rolimus
 5mg tablet.
PREGNANCY:
 Pregnancy category C Rolimus 5mg is 
needed only by the patients after 
knowing the benefits to the mother 
outweighs the risk to fetus.
STORAGE :
 Rolimus 5mg tablet should be kept at 
25°C
Keep the tablet away from moisture, 
heat and light
Dispense only in original container.
MISSED DOSE:
 If patient failed to take a single dose, 
patients must consult with medical 
practitioner and follow the instructions 
given by them. Or the missed dose 
should be avoiding and follow the 
regular dosing schedule.
OVERDOSAGE:
 The over dosage of Everolimus is rarely 
occur, in case of over dosage patient 
must be provide with supportive 
measures. The acute toxicity of 
Everolimus over dosage should be 
monitored.
CONTACT US:
 PHONE NO:+91-9940472902
 EMAIL:millionhealthpharmaceuticals@gm
ail.com
 WEBSITE URL:
https://millionpharma.com/rolimus-5-mg.php