Aspadol (Tapentadol) is one of the most-prescribed medications for relieving chronic and acute pain following a major injury/surgery. Patients with long-term pain management are advised with extended-release Tapentadol tablets administration. The prolonged-release Tapentadol tablets are potent, centrally acting analgesics aimed at inducing analgesia through its dual mechanism action; inhibition of noradrenaline reuptake, and agonism.