Role of Hormonal Therapy in the Management of Prostate Cancer
                     Role of Hormonal Therapy in the 
Management of Prostate Cancer
Role of Hormonal Hormonal therapy, also known as androgen 
deprivation therapy (ADT), plays a vital role 
Therapy in the in the management of prostate cancer, 
particularly in advanced and metastatic 
Management of cases. Prostate cancer growth is largely 
Prostate Cancer driven by androgens, such as testosterone, which stimulate cancer cell proliferation. 
Hormonal therapy aims to reduce the 
production or block the action of these 
hormones, thereby slowing disease 
progression and alleviating symptoms. 
Hormonal therapy, also known as androgen deprivation therapy 
(ADT), is a key treatment for prostate cancer, especially in 
advanced or metastatic stages.
It works by reducing the levels of male hormones (androgens) 
like testosterone or blocking their action, since androgens fuel 
the growth of prostate cancer cells.
Hormonal therapy can be used:
● As a primary treatment in advanced cases.
● In combination with radiation therapy or surgery.
● For biochemical recurrence (rising PSA after initial 
treatment).
Common hormonal therapy methods include:
● LHRH agonists/antagonists (e.g., leuprolide, degarelix)
● Anti-androgens (e.g., bicalutamide, enzalutamide)
● Surgical orchiectomy (removal of testes)
Goals of hormonal therapy:
● Slow tumor growth
● Reduce symptoms
● Improve survival in advanced cases
Side effects may include:
● Fatigue
● Loss of libido
● Erectile dysfunction
● Hot flashes
● Bone thinning (osteoporosis)
● Metabolic changes
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