Aminoglycosides
                     Aminoglycosides
Aminoglycosides are a class of antibiotics used to treat serious 
infections caused by bacteria that either multiply very quickly 
or are difficult to treat.
INTRODUCTION
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Aminoglycosides are called bactericidal antibiotics because they 
kill bacteria directly. They accomplish this by stopping bacteria 
from producing proteins needed for their survival.
BACTERICIDAL 
ANTIBIOTICS 
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Because aminoglycosides are normally used to treat serious 
infections, they are typically administered into the veins of the 
body (intravenously, or IV). However, some aminoglycosides 
can be taken orally, or as ear or eye drops.
TREATMENT
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1. Gentamicin (generic version is IV only)
2. Amikacin (IV only)
3. Tobramycin
4. Gentak and Genoptic (eye drops)
5. Kanamycin
6. Streptomycin
7. Neo-Fradin (oral)
EXAMPLES 8. Neomycin (generic version is IV only)
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1. Are allergic to sulfites (often found in certain wines and 
dried fruits)
2. Have kidney or hearing problems, including problems with 
balance and uncontrollable eye movements
3. Have a disorder affecting the nerves and muscles, like 
multiple sclerosis or myasthenia gravis.
Ask about 
aminoglycosides
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1. Damage to the hearing structures in the ear, resulting in 
hearing loss
2. Damage to the inner ear, resulting in trouble maintaining 
balance
3. Kidney damage (noted by protein in the urine, dehydration, 
and low levels of magnesium)
Common Side 4. Paralysis of skeletal muscles
Effects
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1. Theracrys (BCG live intravesical)
2. Vistide (cidofovir)
3. Zanosar (streptozocin)
Drug 
Interactions
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Although side effects and their severity may vary from person 
to person, the higher the dose of an aminoglycoside you 
receive, or the longer the duration of use, the greater your risk 
of side effects.
Dose of Drug
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