Systemic Pharmacology
                     Systemic 
Pharmacology
Introduction
A Systematic Pharmacology 
and In Vitro Study to Identify 
the Role of the Active 
Compounds of Achyranthes 
bidentata in the Treatment of 
Osteoarthritis
Source: www.ncbi.nlm.nih.gov
Systematic 
pharmacolog
y
This study aimed to identify 
active compounds from 
Achyranthes bidentata 
through systematic 
pharmacology and in vitro 
experiments to find the 
targets of Achyranthes 
bidentata in the treatment of 
OA.
Source: www.ncbi.nlm.nih.gov
Pharmacolog
y
Pharmacology is the study of 
interaction of drugs with living 
organisms.
It also includes history, source, 
physicochemical properties, 
dosage forms, methods of 
administration, absorption, 
distribution mechanism of 
action, biotransformation, 
excretion, clinical uses and 
adverse effects of drugs. 
Source: www.cartercenter.org
Clinical 
Pharmacolog
y
 It evaluate the 
pharmacological action of 
drug preferred route of 
administration and safe 
dosage range in human by 
clinical trails. 
Source: www.cartercenter.org
Drugs
Drugs are chemicals that 
alter functions of living 
organisms. Drugs are 
generally given for the 
diagnosis, prevention, control 
or cure of disease.
Source: www.cartercenter.org
Site of drug 
action
- A drug may act:
(i) Extracellularly e.g: osmotic 
diuretics, plasma expanders.
(ii) On the cell surface e.g.: 
digitalis, penicillin, 
catecholamines
(iii) Inside the cell e.g.: anti-
cancer drugs, steroid 
hormones. 
Source: www.cartercenter.org
Dose 
Response 
relationship
The exact relationship 
between the dose and the 
response depends on the 
biological object under 
observation and the drug 
employed.
Source: www.cartercenter.org
Structural 
activity 
relationship
The activity of a drug is 
intimately related to its chemical 
structure. Knowledge about the 
chemical structure of a drug is 
useful for:
(i) Synthesis of new compounds 
with more specific actions and 
fewer adverse reactions
(ii) Synthesis of competitive 
antagonist 
Source: www.cartercenter.org
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