Link between Cancer and Hormone replacement therapy - Pubrica
                     LINK BETWEEN CANCER 
 AND HORMONE  
REPLACEMENT 
THERAPY
An Academic presentation by
Dr. Nancy Agens, Head, Technical Operations, 
Pubrica  Group: www.pubrica.com
Email: [email protected]
Today's 
Discussion
Outline of In brief
Topics Introduction
Menopausal Hormone Therapy 
(MHT)  What Research Says
Does Hormone Replacement 
Therapy (HRT) Increase Risk
Conclusion  
Future 
Scopes
In 
Brief
Usage of Hormonal Replacement Therapy has its advantages and  
disadvantages. Women should be careful in selecting hormone  
treatments. It is better to review the treatment intake every once in six 
 months to understand its mechanism.
Menopausal Hormone Therapy has mainly used in Western
countries since 1970.
Women tend to start MHT at around menopause and may 
 continue for several years.
Introductio
n Breast cancer at these ages is the most common malignancy 
 in Western countries and diagnosed in about 3% of women in 
 their 50s.
Most individual works were too limited to accurately analyse the 
 long-term risk of breast cancer associated with the use of MHT  
in just a few years.
Menopausal Hormone Therapy 
(MHT)
Menopausal hormone therapy (MHT) affords fantastic relief from climacteric symptoms, 
 but some are associated with increased risk of stroke, venous thromboembolism, and 
 cancers of the breast, ovary and endometrial.
The Women’s Health Initiative trial and the Million Women Study has highlighted the effects 
 of prescribing Hormone therapy and its association on the risk of breast cancer.
However, there are limitations in the way data were obtained and analysed in most 
 epidemiological studies published.
This article will highlight the actual relationship between cancer and hormone 
therapy.
What Research 
Says
Hormones can kill cancer cells in different cases, cause cancer cells to grow extra 
 slowly, or abandon them from growing.
Systemic hormone treatment users who began around the time of menopause have  
been at higher risk of invasive breast cancer than users who never apparently consume.
The risk used to be higher for estrogen-progestagen than for estrogen-only  
preparations, especially if they use progestagen as a substitute once a day rather than 
 an intermittent one.
Does Hormone Replacement Therapy (HRT) 
Increase Risk
The risk of breast cancer will increase for postmenopausal women taking some type of HRT.
But for those who use combined HRT, which has estrogen and progestogen hormones, this is  
the maximum.
Womb cancer threat differs depending on the type of HRT.
Oestrogen-only HRT increases the risk of cancer from the womb.
Oestrogen-only HRT is typically given exclusively to those who have removed two of their  
wombs because they have no womb to continue with cancer hazard.
Conclusio
n
One difficulty of all the handy epidemiological evidence is that after cessation of  
extended use of MHT by women who started some years of hormonal therapy at around 
 the time of menopause, there is still not long enough follow-up.
Another problem is that the collaboration sought statistics only on the incidence of breast  
cancer, not mortality now, and the incidence may depend on the sensitivity and frequency 
 of mammographic screening.
Future 
Scopes
The attitude towards the usage of Hormonal replacement therapy should be encouraged.
The usage of HRT can be used for the momentary remedy of menopausal signs.  
Women thinking about the use of HRT need to be informed of its risks and benefits. 
 Hormonal therapy should not be used for the prevention of any disease.
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