Magnesium The First Line of Psychiatric Depression Defence - Pubrica
                     MAGNESIUM: THE 
FIRST  LINE OF 
PSYCHIATRIC  
DEPRESSION DEFENCE
An Academic presentation by
Dr. Nancy Agens, Head, Technical Operations, 
Pubrica  Group: www.pubrica.com
Email: [email protected]
Today's 
Discussion
Outlin Introduction
e The Role of Magnesium in our 
Body  The Ways Magnesium gets 
Depleted  Effects of Magnesium 
Administration
Introductio
n
World Health Report states that depression accounts for 40% of all 
 neuropsychiatric disorders.
Depression is a disease characterized by a lack of energy, mood 
swings, fluctuations
in weight, interrupted sleep, waking up very early morning, gain or 
loss of appetite, etc.
Reduction in brain magnesium levels results in lowering of 
serotonin.
Major depression is terminated with oral and intravenous administration of magnesium. 
 Administration of antidepressant drugs raises the level of magnesium concentration.
Role of Magnesium in our 
Body
Magnesium plays a crucial role in medical regulating contraction of all kinds of  
muscles, blood pressure, metabolism of insulin, synthesis of DNA, RNA and proteins.
In clinical care, the central nervous system has the maximum concentration of 
 magnesium which accounts for brain balance.
Magnesium acts as a voltage-dependent blocker of N-methyl-D-aspartate channel. 
 This channel is responsible for regulating the flow of calcium to the neuron.
In such medical conditions, calcium and glutamate are take up by the neuron instead  
magnesium, which in turn leads to deregulation of synaptic function, finally leading to 
 the condition of depression.
Ways Magnesium gets 
Depleted
Processed foods lack magnesium and their intake results in magnesium deficiency
in our body.
Black beans, pumpkin seeds, cashews, almonds and dark chocolate are some of the 
 food items rich in magnesium.
Intake of antacids, diuretics, caffeine and alcohol also decreases magnesium levels. 
 Use of pesticides and potassium-based fertilizers causes magnesium depletion.
Pesticides kill the important magnesium absorbing bacteria, while potassium of 
 fertilizers is taken up by the plants instead of magnesium and calcium.
Effects of Magnesium 
Administration
The positive side is that mood and cognition gets improved and better with the 
 administration of magnesium such that the normal levels of magnesium gets 
 restored in the body.
People tend to show healthy eating patterns, better quality of sleep, 
improvements in
efficacy of modalities such as medications, etc.
Minerals like magnesium are required in very small amounts in our body but play 
 major roles in several metabolic pathways.
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