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The results showed that the release of GH using 
About MK-677 does not significantly affect the plasma level of aldosterone, prolactin, luteinizing 
hormone, and thyroxine after oral administration 
of 1mg/kg [4]. The results showed an increase in 
cortisol. Thus, the MK-677 was selected for 
clinical studies.
MK-677 is known as L-163,191 in different scientific articles 
[4] [5]. In 1995, A group of research at Merck discovered a 
receptor to which MK-677 binds. Ibutamoren MK 677 is a 
derivatized dipeptide which is used in clinical trial as oral 
active GHS. The reason that GHS is consider the best oral 
active drug among others: GHRH, SRIF, and hHG is its low 
molecular weight [4].
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