More about Aseptic Process Development
                     More about Aseptic Process 
Development
Aseptic processing is a manufacturing method that can produce a product absent of 
bacteria without subjecting the product to terminal sterilization processes. However, 
many products subjected to harsh conditions of terminal sterilization degrade and 
become ineffective. Therefore aseptic processing equipment allows these products to 
be produced in a sterile environment, allowing them to maintain their effectiveness 
while being safe to inject into patients.
There's a drastic shift for beverage producers as a result of aseptic filling technology 
development. Back then, shelf life was achieved through hot fill technology such that, 
in effect, the sterilized bottle with hot liquid was part of the filling process. Despite 
the effectiveness of the technology, it still had some product limitations in quality. 
plastic design bottles were limited with the inability to withstand heat applied during 
filling without distortion. In comparison, cold aseptic processing equipment provides 
the required shelf life without adversely affecting product quality. The technology 
uses fewer plastic bottles. it gives greater flexibility in designing the bottles.
Aseptic Processing Equipment
With globalization, aseptic technology aims to achieve accuracy, best-filling speed, and 
flexibility while maintaining the sterility of product and container during the whole 
process. It also aims to avoid recontamination. 
The filing environment must be aseptic, which means the whole area must be thoroughly 
sterilized and cleaned using decisive mechanical actions and proper chemicals. 
Immediately after filling, any residue must be removed to avoid the risk of 
microorganisms' growth. 
The containers can be filled by weight or volume. The volumetric filling uses a magnetic 
flow meter fitted to each filling head to control liquid flow accurately. Since most aseptic 
products are liquids, they can still be bottled without the filling head touching the bottle. 
However, products that are subject to foaming make it necessary to ensure a careful 
control flow rate. it varies during each filling bottle in order to achieve the required 
accuracy.
Filling by weight in turn is reserved by liquid products whose quantity packaging are 
declared in grams. It's also used as a second check to take account of variation caused by 
product viscosity or temperatures. Filing by weight might become testing to control in 
rapid tasks, for example, impact and vibration inside the framework, which influences the 
estimations.
Why Should Manufacturers Establish Environmental Control For 
Aseptic Processes?
Typically, all drug manufacturing, including solid oral dosage form and terminal 
sterilization manufacturing, must have established environmental controls. It is a 
requirement addressed in global current good manufacturing practices. It's enforced this 
way to prevent contamination as a result of insanitary conditions. The environment 
control measures to be monitored include temperature, humidity, ventilation, air 
pressure, air quality including particulate matter, and microbial contamination. however, 
the environment control limits are stricter for aseptic manufacturers due to the nature of 
the business.
Contact Details
MicroThermics, Inc. 3216-102 Wellington Ct.
Raleigh, NC 27615, USA
Phone: +1 919 878 8045
Fax: +1 919 878 8032
Email: [email protected] 
Website : https://microthermics.com